Anti-inflammatory and anti-apoptotic activity of synaptamide improves the morphological state of neurons in traumatic brain injury.

Traumatic brain injuries (TBI) of varying severity are becoming more frequent all over the world. The process of neuroinflammation, in which macrophages and microglia are key players, underlies all types of brain damage. The present study focuses on evaluating the therapeutic potential of N-docosahexaenoylethanolamine (DHEA, synaptamide), which is an endogenous metabolite of docosahexaenoic acid in traumatic brain injury.

Existence of edge modes in periodic microstrip transmission line.

The microstrip of modulated width is a realization of a one-dimensional photonic crystal operating in the microwave regime. Like any photonic crystal, the periodic microstrip is characterised by the presence of frequency bands and band gaps that enable and prohibit wave propagation, respectively. The frequency bands for microstrip of the symmetric unit cell can be distinguished by 0 or Zak phase.

WntA and Wnt4 during the regeneration of internal organs in the holothurian Eupentacta fraudatrix.

Background: Over the past few years, it has been established that wnt genes are involved in the regenerative processes of holothurians. The wnt4 gene was identified as one of the most active genes in Eupentacta fraudatrix regeneration using differential gene expression analysis and qPCR of individual genes. Also, the wntA gene was found in holothurians, which is present only in invertebrates and can perform unique functions.

Role of smoothened and sfrp genes in Eupentacta fraudatrix regeneration.

The secreted frizzled-related proteins (sfrp) and smoothened (smo) genes and their possible role in the regeneration of internal organs in the holothurian Eupentacta fraudatrix were studied. In this species, two sfrp genes were identified: sfrp1/2/5, sfrp3/4 and one smo gene. Their expression was analysed during regeneration of the aquapharyngeal bulb (AB) and intestine, and these genes were knock down by RNA interference.

Enhancement of the microwave photon-magnon coupling strength for a planar fabricated resonator.

Planar resonators have a wide usage in modern microwave technologies and perspectives in novel quantum technologies development. As was demonstrated earlier, their utilization allows to achieve high values of microwave photon-magnon coupling strength-an important parameter in technologies of information coherent transfer from electromagnetic GHz range to the optical range. In the present work, the achievement of the high value of the microwave photon-magnon coupling strength by exploiting the increase of the spatial concentration of the magnetic component of the planar resonator electromagnetic field is reported.

Expression of , , , and during Gut Regeneration in Holothurian (Holothuroidea, Dendrochirotida).

Mesodermal cells of holothurian can transdifferentiate into enterocytes during the regeneration of the digestive system. In this study, we investigated the expression of several genes involved in gut regeneration in Moreover, the localization of progenitor cells of coelomocytes, juvenile cells, and their participation in the formation of the luminal epithelium of the digestive tube were studied. It was shown that Piwi-positive cells were not involved in the formation of the luminal epithelium of the digestive tube.

The Eupentacta fraudatrix transcriptome provides insights into regulation of cell transdifferentiation.

The holothurian Eupentacta fraudatrix is a unique organism for studying regeneration mechanisms. Moreover, E. fraudatrix can quickly restore parts of its body and entire organ systems, yet at the moment, there is no data on the participation of stem cells in the process.

Reference assembly and gene expression analysis of Apostichopus japonicus larval development.

The transcriptome of the holothurian Apostichopus japonicus was sequenced at four developmental stages-blastula, gastrula, auricularia, pentactula-on an Illumina sequencer. Based on our RNA-seq data and the paired-end reads from 16 libraries obtained by other researchers earlier, we have achieved the currently most complete transcriptome assembly for A. japonicus with the best basic statistical parameters.

Wnt and frizzled expression during regeneration of internal organs in the holothurian Eupentacta fraudatrix.

Several genes of the Wnt and Frizzled families in the holothurian Eupentacta fraudatrix are characterized, and the complete coding sequences of wntA, wnt4, wnt6, wnt16, frizzled1/2/7, frizzled4, and frizzled5/8 are obtained. The dynamics of expression of these genes during regeneration of internal organs after evisceration are studied. Evisceration and the associated damages supposedly induce the expression of wnt16 on third day after evisceration.

[Bacteriological and pathomorphological control of the effectiveness of the therapy of experimental pyocyanic burn infection].

Bacteriological and pathomorphological characteristics of experimental pyocyanic burn infection in noninbred albino mice are presented. The model was used for comparative investigation of the chemotherapeutic efficacy of quinoxidin, dioxidin, carbenicillin and gentamicin. The chemotherapeutic efficacy of quinoxidin and dioxidin was shown to be higher than that of carbenicillin and gentamicin with respect to both the bacteriological criteria and the pathomorphological indices.

[Experimental therapy of burn infection caused by pyocyanic bacilli].

The chemotherapeutic effect of di-N-quinoxaline oxide derivatives--quinoxidine and diaxidine, as contrasted to that of carbenicillin and hentamycin with their 3- and 10-day application, was studied on a model of a burn in mice infected with Pseudomonas eruginosa. The results achieved by the quinoxidine and dioxidine medication proved much better than those obtained by the use of carbenicillin and hentamycin.