Publications by authors named "Giri Debasish"
Article Synopsis
- - Monocarboxylate transporter 8 (MCT8) is essential for transporting thyroid hormones T4 and T3 into cells, and mutations in its gene (SLC16A2) can cause Allan-Herndon-Dudley Syndrome (AHDS), a neurological disorder.
- - Researchers created a new fluorescent assay to observe thyroid hormone uptake via MCT8, utilizing a dansyl-based probe that is selectively recognized by the transporter in living cells.
- - The probe's specificity for MCT8 relies on a halogen bond interaction and the presence of a free carboxylic acid group; altering this group or adding a free amine disrupts recognition by MCT8.
The regioselective deiodinations of L-thyroxine (T4) play key roles in the thyroid hormone homeostasis. These reactions are catalyzed by three isoforms of the selenoenzymes, iodothyronine deiodinases (Dio1, Dio2 and Dio3), which are highly homologous in nature. Dio1 mediates 5'- or 5-deiodinations of T4 to produce T3 and rT3, respectively.
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