Publications by authors named "Giovanni Salvatore Bruni"
Article Synopsis
- Epithelial ovarian cancer is the most prevalent type, primarily affecting women over 50, and is often diagnosed at advanced stages (III or IV), leading to a poor prognosis.
- Treatment typically involves a combination of surgery and chemotherapy, which is crucial for both early and advanced cases.
- Recent years have seen the introduction of several new drugs for treatment, with ongoing research into novel targets and agents for improved outcomes.
Article Synopsis
- Epithelial ovarian cancer is the fourth leading cause of cancer deaths among women, but treatment outcomes have improved recently, particularly with surgical staging and the carboplatin-paclitaxel chemotherapy regimen.
- Despite effective initial treatments, long-term survival rates are still low, and many patients experience significant recurrences and side effects that impact quality of life, like hair loss and fatigue.
- Over the past decade, more than 10,000 women have participated in trials exploring new chemotherapy options, such as intraperitoneal treatments and different drug combinations, to enhance efficacy and minimize side effects, with ongoing studies focusing on targeted and biological therapies.
Article Synopsis
- Imatinib mesylate (STI-571) is a key treatment that targets the KIT enzyme, significantly improving outcomes for patients with metastatic GIST but can lead to resistance over time due to mutations.
- New strategies, including the use of additional drugs like mTOR inhibitors and other KIT inhibitors, are being explored to overcome this resistance and enhance treatment effectiveness.
The present study was conducted to evaluate activity and toxicity of the FLEC (folinic acid 100 mg/m2; 5-fluorouracil 1000 mg/m2; carboplatin 300 mg/m2; epirubicin 60 mg/m2) schedule as second-line treatment for progressive locally advanced or metastatic pancreatic cancer (LAMPC). FLEC was administered every 3 weeks with an angiographic catheter introduced into the tumor vascular bed. Thirty-two patients were enrolled.
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