Publications by authors named "Giovanni Pintus"
Article Synopsis
- Methylmalonic Aciduria (MA) is a rare disorder that leads to toxic methylmalonic acid buildup, causing serious health issues like metabolic crises and kidney damage.
- A case study of a 39-year-old male with MA and stage IV chronic kidney disease illustrates how a single hemodialysis session effectively treated his acute metabolic crisis after a gastrointestinal infection.
- Long-term management of MA often requires continuous kidney and/or liver transplantation, with combined liver-kidney transplants offering better outcomes due to reduced acid production and improved kidney function.
The exclusion of causes of hypertension is not systematically exploited in clinical practice. Therefore, essential hypertension is consistently presented as the most prevalent 'cause'. The paradox of a condition with unknown causes being described as a common cause of hypertension translates into a diagnosis of essential hypertension in most patients, which precludes the detection of a curable cause of hypertension.
View Article and Find Full Text PDFBackground: Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hypokalemia and uncontrolled high blood pressure. Our aim was to investigate if unilateral PA can be identified by AVS during MRA treatment.
Methods: We compared the rate of unilateral PA identification between patients with and without MRA treatment in large data sets of patients submitted to AVS while off renin-angiotensin system blockers and β-blockers.
Introduction: Vascular access recirculation during hemodialysis is associated with reduced effectiveness and worse survival outcomes. To evaluate recirculation, an increase in pCO in the blood of the arterial line during hemodialysis (threshold of 4.5 mmHg) was proposed.
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- Prevention campaigns have successfully reduced new HIV diagnoses in Western Europe, but awareness of other STIs among the general population, particularly in Italy, remains low, especially among individuals over 50 years old.
- A questionnaire distributed to 2183 people revealed that many lacked knowledge about safe practices and the Undetectable = Untransmittable (U = U) initiative, with 97.6% agreeing that more educational campaigns are necessary.
- The study emphasized the need for tailored educational efforts, indicating that surveys can be effective tools for raising awareness and improving knowledge about HIV and STIs across different demographic groups.
Background: Renal Ultra-Sound (US) and Doppler US provide measurements which reflect changes in renal and systemic haemodynamic. The renal resistive index (RRI), obtained through the Doppler spectrum analysis of renal small arteries, is altered in several pathologic conditions. Glomerulonephritis cause minor RRI changes, while renal scleroderma vasculopathy (RSV) leads to significant RRI modifications.
View Article and Find Full Text PDFIntroduction: The gut microbiota has coevolved with humans for a mutually beneficial coexistence and plays an important role in health and disease. A dysbiotic gut microbiome may contribute to progression to chronic kidney disease (CKD) and CKD-related complications such as cardiovascular disease. Microbiota modulation through the administration of prebiotics may represent an important therapeutic target.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) is a highly prevalent condition. Urologic disorders are known causes of CKD, but often remain undiagnosed and underestimated also for their insidious onset and slow progression. We aimed to evaluate the prevalence of urological unrecognized diseases in CKD patients by uroflowmetry.
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