Risk and triggering factors for diffuse alveolar hemorrhage in primary antiphospholipid syndrome. An observational follow-up study and a systematic review of the literature.

Background: Diffuse alveolar hemorrhage (DAH) represents a serious, life-threatening complication of primary antiphospholipid syndrome (PAPS), a thrombophilic disorder mainly characterized by vascular thrombosis and/or pregnancy morbidity. Risk factors for DAH in PAPS patients and the comorbidities that may trigger DAH were investigated here in the effort to identify possible independent predictors of DAH in PAPS patients.

Methods: Only PAPS patients fulfilling the Sydney criteria were taken into consideration.

Purine metabolism and hyperuricemic states. 'The point of view of the rheumatologist'.

Gout is among the most common causes of acute monoarticular arthritis. It is characterized by depositions of monosodium urate crystals in a joint or in soft tissues, causing an acute inflammatory response. Gout typically occurs in middle age and more commonly in men.