Modeling PrP Generation Through Deformed Templating.

Deformed templating is the process by which self-replicating protein conformations with a given cross-β folding pattern can seed formation of an alternative self-replicating state with different cross-β folding pattern. In particular, uninfectious but propagative PrP amyloid can transform into a infectious conformer, PrP through deformed templating. The process can take many rounds of replication (if taking place ) or even several passages of the evolving PrP conformers through successive brains if , through experimental transmission.