Publications by authors named "Giovanni Moioli"
Pyelo-hepatic abscess is a rare complication of upper urinary tract infections (UTIs). We describe a case of polymicrobial pyelo-hepatic abscess in an immunocompetent patient. A 71-year-old male patient with a double-J stent for right ureteral lithiasis was admitted in our Infectious Diseases Department for a pyelo-hepatic abscess.
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- Klebsiella pneumoniae (K. pneumoniae) is a common gut bacterium that can cause serious infections, including liver abscesses, particularly in Asian populations, but reports are increasing in Western countries.
- A case in Italy presented a healthy Chinese individual with a pyogenic liver abscess caused by hypervirulent K. pneumoniae, which also led to complications like endophthalmitis and infections in the lungs and prostate, despite no recent travel to Asia.
- This case emphasizes the importance of being aware of hypervirulent K. pneumoniae even in areas where it is rare and without clear epidemiological connections.
Background: COVID-19 and its related anti-inflammatory treatment (steroids, immunomodulators) may induce the reactivation of latent bacterial, parasitic, and viral infections. According to our knowledge, no case of disseminated HHV-8-related Kaposi sarcoma (KS) after COVID-19 and its treatment has been described so far. Only one case of cutaneous KS concurrently with COVID-19 has been previously reported.
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- - The study analyzed the occurrence and effects of superinfections in COVID-19 patients with acute respiratory distress syndrome in an ICU setting, finding that 57.6% of patients had at least one superinfection during their stay.
- - Ventilator-associated pneumonia was the most common, with bacteria like K. pneumoniae and P. aeruginosa being significant culprits, while bloodstream infections and fungal infections were also reported.
- - Key factors that increased the risk of ICU or 28-day mortality included the presence of bacterial infections, older age, and a higher Sequential Organ Failure Assessment score.
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- CMV infection poses significant challenges in allogeneic stem cell transplantation (allo-SCT), but the introduction of letermovir as a prophylactic treatment for high-risk patients has improved management outcomes.
- A study compared outcomes of patients receiving letermovir (LET) from December 2018 to April 2020 with those who did not receive it (NO LET) between November 2017 and November 2018, revealing substantial reductions in clinically significant CMV infections.
- Additionally, the research found a strong correlation between CMV DNA levels measured in whole blood (WB) and plasma (PL), indicating WB may provide higher DNAemia levels during pre-emptive therapy initiation despite only slightly significant differences.
A hyperinflammatory syndrome (HIS) may cause a life-threatening acute respiratory distress syndrome (ARDS) in patients with COVID-19 pneumonia. A prospective series of 100 consecutive patients admitted to the Spedali Civili University Hospital in Brescia (Italy) between March 9th and March 20th with confirmed COVID-19 pneumonia and ARDS requiring ventilatory support was analyzed to determine whether intravenous administration of tocilizumab (TCZ), a monoclonal antibody that targets the interleukin 6 (IL-6) receptor, was associated with improved outcome. Tocilizumab was administered at a dosage of 8 mg/kg by two consecutive intravenous infusions 12 h apart.
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