Publications by authors named "Giovanni Isgro"
Several studies have demonstrated that, beyond their antithrombotic effects, P2Y12 receptor inhibitors may provide additional off-target effects through different mechanisms. These effects range from the preservation of endothelial barrier function to the modulation of inflammation or stabilization of atherosclerotic plaques, with an impact on different cell types, including endothelial and immune cells. Many P2Y12 inhibitors have been developed, from ticlopidine, the first thienopyridine, to the more potent non-thienopyridine derivatives such as ticagrelor which may promote cardioprotective effects following myocardial infarction (MI) by inhibiting adenosine reuptake through sodium-independent equilibrative nucleoside transporter 1 (ENT1).
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- Aquaporin-4 (AQP4) is a crucial protein involved in the glymphatic system, which facilitates fluid exchange in the brain and is linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia.
- A study analyzed cerebrospinal fluid (CSF) samples from 103 patients with neurodegenerative dementias and found significantly higher AQP4 levels in these patients compared to controls.
- There was also a positive correlation between AQP4 levels and total tau, suggesting that AQP4 could be important for understanding neurodegeneration and may lead to new clinical assessments related to brain health.