Publications by authors named "Giovanni F Porcheddu"
The brain employs distinct circuitries to encode positive and negative valence stimuli, and dysfunctions of these neuronal circuits have a key role in the etiopathogenesis of many psychiatric disorders. The Dorsal Raphè Nucleus (DRN) is involved in various behaviors and drives the emotional response to rewarding and aversive experiences. Whether specific subpopulations of neurons within the DRN encode these behaviors with different valence is still unknown.
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- Epilepsy commonly occurs alongside Alzheimer's disease (AD) and often appears before noticeable memory decline, suggesting a potential link worth studying in early AD stages.
- Research on Tg2576 mice showed that repeated seizures led to memory impairment and increased amyloid-β (Aβ) levels specifically in those with pre-symptomatic AD, indicating a connection between seizures and AD pathology.
- The antiepileptic drug lamotrigine was effective in reversing the neuronal changes and memory deficits caused by seizures, suggesting it could help mitigate the progression of AD in its early stages.