Publications by authors named "Giovanni Enrico Mann"
Page 1 of 1
Synopsis of recent research by authors named "Giovanni Enrico Mann"
- Giovanni Enrico Mann's recent research primarily focuses on the role of heme oxygenase 1 (HO-1) in the context of melanoma treatment, particularly examining its impact on the efficacy of the BRAF inhibitor Vemurafenib/PLX4032 in different oxygen conditions.
- His 2022 study demonstrates that elevated levels of HO-1 contribute to immune evasion in BRAF-mutated melanoma cells, suggesting that traditional cell culture conditions may not fully replicate the tumor microenvironment in vivo.
- The findings highlight the need for more physiological models in cancer research to better understand the adaptive mechanisms of melanoma cells, particularly relating to hypoxic conditions prevalent in the tumor microenvironment.
