Publications by authors named "Giovanni Battista Vingiani"
Article Synopsis
- Ofatumumab (OFA) and ocrelizumab (OCRE) are two monoclonal antibodies used to treat relapsing multiple sclerosis by targeting and depleting B lymphocytes.
- In a study using humanized mice, both OFA and OCRE resulted in over 90% reduction of circulating human CD20+ B lymphocytes, but only OFA showed signs of B lymphocyte replenishment after several weeks.
- OFA treatment preserved bone marrow niches necessary for B cell recovery, while OCRE only maintained preB-I cells, indicating OFA may have a more favorable safety profile regarding infection risk.
The metabolic contribution of the small intestine (SI) is still unclear despite recent studies investigating the involvement of single cells in regional differences. Using untargeted proteomics, we identified regional characteristics of the three intestinal tracts of C57BL/6J mice and found that proteins abundant in the mouse ileum correlated with the high ileal expression of the corresponding genes in humans. In the SI of C57BL/6J mice, we also detected an increasing abundance of lysosomal acid lipase (LAL), which is responsible for degrading triacylglycerols and cholesteryl esters within the lysosome.
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