Publications by authors named "Giovanna Zunta-Soares"
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD.
View Article and Find Full Text PDFDeep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle (MFB) has been reported to lead to rapid antidepressant effects. In this longitudinal study, we expand upon the initial results we reported at 26 weeks (Fenoy et al., 2016), showing sustained antidepressant effects of MFB DBS on six patients with treatment-resistant depression (TRD) over 1 year.
View Article and Find Full Text PDFArticle Synopsis
- Treatment resistant depression (TRD) is a challenging condition, and a new study on deep brain stimulation (DBS) targeting the medial forebrain bundle (MFB) has shown promise for rapid antidepressant effects in some patients.
- An interim analysis showed that three out of four patients experienced significant improvement in depression symptoms within one week of starting DBS, while one patient did not respond and withdrew from the study.
- Although the findings are preliminary and based on a small sample, they suggest that MFB-DBS may have similar effects to previously reported studies, highlighting the need for further research to confirm its effectiveness.
Objective: To assess clinical outcomes associated with the presence of a lifetime history of comorbid posttraumatic stress disorder in subjects with bipolar disorder.
Methods: This cross-sectional study of 284 subjects with bipolar disorder (DSM-IV) assessed the association between lifetime comorbid posttraumatic stress disorder (DSM-IV) and clinical characteristics. Participants were included from January 2006 to June 2009.
Objective: The current study evaluated the effects of chronic administration of lithium on renal functioning in an intellectually disabled population.
Methods: Fifty-seven lithium-treated individuals were compared with 24 behaviorally symptomatic controls using a retrospective chart review method. Serum creatinine levels and creatinine clearance activities were compared at baseline, at the time of peak creatinine levels, and at the end of the study in 2006.