Systemic Lupus Erythematosus (SLE) can lead to Lupus Nephritis (LN), causing podocyte injuries in kidneys, which are crucial for understanding disease mechanisms.
A study analyzed 29 LN biopsy cases and 20 control cases, focusing on podocyte density and foot process effacement, using advanced imaging techniques.
Results showed significantly lower podocyte density and increased foot process effacement in LN patients, particularly in specific classes, indicating a correlation between podocyte injury severity and inflammatory activity.