Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients.

Objective: To determine the association of insulin sensitivity and metabolic status with declining cognition in HIV-infected individuals.

Methods: We conducted targeted clinical and metabolic measures in longitudinal plasma samples obtained from HIV-infected patients enrolled in the Central Nervous System HIV Anti-Retroviral Therapy Effects Research Study (CHARTER). Findings were validated with plasma samples from the Multicenter AIDS Cohort Study (MACS).