Publications by authors named "Giovanna Nascimento Scatolin"
Article Synopsis
- DNA replication timing in differentiated cells is predetermined, but the establishment of this timing during mammalian development is unclear; new research reveals key insights into this process.
- Using single-cell sequencing, scientists found that late replicating regions are linked with the B compartment and nuclear lamina from the very first cell cycle post-fertilization in both maternal and paternal genomes.
- The study indicates that these late replicating areas are prone to chromosome breaks and fragility, particularly affecting long neuronal genes before the differentiation of somatic and germ cell lineages, highlighting early genome organization after fertilization.
Article Synopsis
- A thorough understanding of molecular and cellular processes during peri-implantation is crucial for improving pregnancy outcomes, which is when most pregnancy failures happen.
- Researchers analyzed single-cell transcriptomes of bovine embryos at different peri-implantation stages (days 12, 14, 16, and 18) to identify cell types and gene expression patterns in important embryonic structures.
- The study unveiled a new primitive trophoblast lineage and highlighted similarities and differences in developmental processes between bovines and other mammals, emphasizing the importance of cell communication for healthy early development.
Unlabelled: Supporting healthy pregnancy outcomes requires a comprehensive understanding of the cellular hierarchy and underlying molecular mechanisms during peri-implantation development. Here, we present a single-cell transcriptome-wide view of the bovine peri-implantation embryo development at day 12, 14, 16 and 18, when most of the pregnancy failure occurs in cattle. We defined the development and dynamic progression of cellular composition and gene expression of embryonic disc, hypoblast, and trophoblast lineages during bovine peri-implantation development.
View Article and Find Full Text PDF