Publications by authors named "Giovanna Mendoza-Mujica"
Article Synopsis
- Carrion's disease, a neglected tropical illness in the Andean region, has a high mortality rate of up to 88% without treatment, highlighting the urgent need for better diagnostic methods.
- Current serological tests for the disease lack sensitivity and specificity, prompting the exploration of recombinant proteins as potential improvements in diagnosis.
- Research focused on producing two proteins using the baculovirus-insect cell system found optimal conditions for high yields, which could enhance diagnostic tools and inform future therapy development.
Single-nucleotide polymorphisms in ialB, gltA and rpoB genes of Bartonella bacilliformis isolated from patients in endemic Peruvian regions.
PLoS Negl Trop Dis
October 2023
Bartonella bacilliformis is a Gram-negative, aerobic bacterium and the known causal agent of Carrion's disease, still considered a neglected disease. There is limited information about the nucleotide sequences of this bacterium in international databases, and few studies have addressed the genetic diversity of B. bacilliformis.
View Article and Find Full Text PDFCarrion´s disease is caused by Bartonella bacilliformis, it is a Gram-negative pleomorphic bacterium. B. bacilliformis is transmitted by Lutzomyia verrucarum in endemic areas of the Peruvian Inter-Andean valleys.
View Article and Find Full Text PDFThe presence of amino acid changes in GyrA, GyrB, ParC, ParE, and in a proposed chromosomal chloramphenicol acetyl transferase (CAT), as well as mutations at , were established by PCR and sequencing in 38 clinical isolates from four different areas in Peru. Eighteen out of 24 (75%) isolates showing ciprofloxacin resistance for both disk-diffusion and e-test presented amino acid substitutions in GyrA (GC, six isolates, AV, 1 isolate) GyrB (SF, 10 isolates) or both (GyrA DN and GyrB SF, one isolate). Two out of 14 susceptible isolates presented amino acid substitutions at GyrB (SF) or a double substitution GyrA DN and GyrB SF.
View Article and Find Full Text PDF[Antimicrobial resistance of Bartonella bacilliformis strains from regions endemic to bartonellosis in Peru].
Rev Peru Med Exp Salud Publica
October 2015
Article Synopsis
- The study aimed to assess how effective two antibiotics, chloramphenicol (CHL) and ciprofloxacin (CIP), are against strains of Bartonella bacilliformis in Peru using three laboratory testing methods.
- Out of 100 strains tested, 26% were resistant to CIP while only 1% showed resistance to CHL, with consistent results across all testing methods.
- The findings suggest that there is a significant resistance issue with CIP, highlighting the need for further research into treatment options for Bartonellosis, and established that E-test and disk diffusion are reliable methods for measuring antibiotic effectiveness.