Publications by authors named "Giovanna Braganza"
Background: We have an incomplete understanding of COVID-19 characteristics at hospital presentation and whether underlying subphenotypes are associated with clinical outcomes and therapeutic responses.
Methods: For this cross-sectional study, we extracted electronic health data from adults hospitalized between 1 March and 30 August 2020 with a PCR-confirmed diagnosis of COVID-19 at five New York City Hospitals. We obtained clinical and laboratory data from the first 24 h of the patient's hospitalization.
Purpose: As polygenic risk scores (PRS) emerge as promising tools to inform clinical care, there is a pressing need for patient-centered evidence to guide their implementation, particularly in diverse populations. Here, we conducted in-depth interviews of diverse Spanish- and English-speaking patients to explore their perspectives on clinical PRS.
Methods: We enrolled 30 biobank participants aged 35-50 years through a purposive sampling strategy, ensuring that >75% self-reported as African/African American or Hispanic/Latinx and half were Spanish-speaking.
Article Synopsis
- - Population-based genomic screening has the potential to improve health outcomes for diverse populations, but there's a need for more research, especially for those with non-European ancestry, which are often underrepresented in genomics.
- - A pilot program at the BioMe Biobank in NYC focused on screening for genetically linked conditions like hereditary breast and ovarian cancer, Lynch syndrome, familial hypercholesterolemia, and included the TTR gene relevant for those with African ancestry.
- - Results showed that the majority of participants receiving results for the TTR gene were African American or Hispanic/Latinx, with a high interest (over 93%) in receiving genomic results, especially among younger individuals and women.
Article Synopsis
- The TTR V142I variant is linked to hereditary transthyretin amyloidosis (hATTR) and is notably present in up to 4% of African Americans and 1% of Hispanic/Latinx individuals, increasing their risk for heart failure.* -
- A study evaluated the effectiveness of genomic screening in identifying individuals at risk for hATTR by reviewing medical records of participants who received TTR V142I results through a pilot program in New York City.* -
- Findings showed that over half of the screened individuals had hATTR-related symptoms, with some pursuing follow-up care, indicating that genomic screening can facilitate earlier diagnosis and management of hATTR risk.*
Purpose: Although sleep disturbances are common in older adults, studies evaluating the prevalence of sleep disturbance and its influence on functional outcomes in older adults with cancer are few. In this study, we examined the prevalence of sleep disturbance and its association with physical function and cognition in older adults with cancer.
Methods: This is a cross-sectional study of patients who were referred and evaluated in the Specialized Oncology Care & Research in the Elderly (SOCARE) clinics at the Universities of Rochester and Chicago from May 2011 to October 2015.