Publications by authors named "Giovana T Capoani"
Hydroalcoholic Extract of Centella asiatica and Madecassic Acid Reverse Depressive-Like Behaviors, Inflammation and Oxidative Stress in Adult Rats Submitted to Stress in Early Life.
Amanda Gollo Bertollo Maiqueli Eduarda Dama Mingoti Jesiel de Medeiros Gilnei Bruno da Silva Giovana Tamara Capoani
Mol Neurobiol
December 2024
Article Synopsis
- Major depressive disorder (MDD) significantly impacts quality of life, particularly linked to stress from maternal deprivation (MD), and traditional treatments often have serious side effects.
- Centella asiatica (C. asiatica) and its compound madecassic acid show promise for alleviating depressive-like behaviors and reducing inflammation and oxidative stress in young rats subjected to MD.
- The study demonstrated that treatment with C. asiatica extracts led to improvements in behavior, decreased inflammatory markers, and reduced oxidative stress in the brain and serum, suggesting their potential as antidepressant agents.
Malpighia emarginata has a high amount of vitamin C with pharmacological or food preservation potential. However, despite its wide use and application possibilities its toxicity in repeated doses and for a long time (6 months) has not yet been studied. In this context, this study aimed to evaluate the acute toxicity and repeated doses from fruits of this plant.
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