Publications by authors named "Giovana R Weber"
Article Synopsis
- Hepatocellular carcinoma (HCC) is a prevalent type of liver cancer that develops through multiple stages, with specific indicators like ductular reaction, PCK7 positivity, and elevated γGT levels playing a key role in tumor development.
- A study was conducted on 24 male Wistar rats to evaluate the relationship between these indicators, cancer stages, and liver damage by inducing HCC through diethylnitrosamine exposure.
- Results showed a significant ductular reaction in advanced HCC, with high levels of PCK7 and γGT linked to more aggressive cancer behavior, while these levels were inversely related to protective proteins that may mitigate oxidative stress.
Ann Hepatol
September 2016
Article Synopsis
- Topical hypothermia (TH) and ischemic preconditioning (IPC) are both strategies investigated for their effectiveness in reducing inflammation and injury caused by ischemia/reperfusion (I/R) in the liver.
- In a study with Wistar rats, TH significantly lowered pro-inflammatory markers while increasing anti-inflammatory markers compared to normothermic ischemia (NI), and TH alone proved more protective than isolated IPC.
- The combination of TH and IPC provided similar benefits to TH alone but did not offer any additional protective effects, specifically in minimizing inflammatory processes.
