Publications by authors named "Giovana P Angelice"
Article Synopsis
- Existing vaccines for hepatitis B are effective, but the virus remains a significant health issue due to challenges like cccDNA and potential reinfection.
- RNA interference (RNAi) is being explored as a promising treatment strategy for chronic hepatitis B, offering a new approach to silence the virus.
- A review analyzed 76,949 studies, narrowing it down to 226 key reports, highlighting RNAi's potential while calling for more research to bridge the gap between laboratory findings and real-world treatment applications.
Hepatitis D virus (HDV) is currently classified into 8 genotypes (1 to 8) and several subgenotypes, with distinct distribution worldwide. However, due to the scarcity of complete genome sequences in databases, this classification is constantly being updated and tends to be regularly revisited in upcoming years as more sequence data becomes available. Aiming to increase knowledge about the genetic variability of HDV, this study presents the full-length genomes of 11 HDV samples collected in Brazil in endemic and non-endemic regions, including the first complete genomes of the genotypes 5 and 8 obtained outside Africa.
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- The study investigates how the host immune system affects the genetic variability of the hepatitis B virus (HBV), focusing on patients with different stages of infection.
- It analyzes DNA samples from 113 individuals to evaluate HBV genetic diversity, resistance to antiviral drugs, and mutations that help the virus evade detection by the immune system.
- Results show that most patients carry genotype A HBV and that those with lower viral loads exhibit higher genetic diversity, indicating they face greater selective pressure from the immune response.
Hepatitis D virus (HDV) is classified into 8 genotypes (1 to 8) and several subgenotypes. In Brazil, HDV-3 and HDV-1 predominate; however, most of the diagnosis efforts and molecular studies are directed to the area of endemicity of the Amazon Basin. Here, we determined the molecular epidemiological profile of circulating HDV in Brazilian HBsAg-positive patients between 2013 and 2015 in areas of endemicity and non-areas of endemicity.
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