Heteroleptic oxidovanadium(IV)-malate complex improves glucose uptake in HepG2 and enhances insulin action in streptozotocin-induced diabetic rats.

Diabetes mellitus, a complex and heterogeneous disease associated with hyperglycemia, is a leading cause of mortality and reduces life expectancy. Vanadium complexes have been studied for the treatment of diabetes. The effect of complex [VO(bpy)(mal)]·HO (complex A) was evaluated in a human hepatocarcinoma (HepG2) cell line and in streptozotocin (STZ)-induced diabetic male Wistar rats conditioned in seven groups with different treatments (n = 10 animals per group).

Polyoxovanadates as new P-glycoprotein inhibitors: insights into the mechanism of inhibition.

A promising strategy to overcome multidrug resistance is the use of inhibitors of ABC drug transporters. For this reason, we evaluated the polyoxovanadates (POVs) [V O ] (V ), [H V O (PO )] (V ), [V O Cl] (V ) and [V O I] (V ) as inhibitors of three major multidrug resistance-linked ABC transporters: P-glycoprotein (P-gp), ABCG2 and MRP1. All of the POVs selectively inhibited P-gp.

An Oxalate-Bridged Copper(II) Complex Combining Monodentate Benzoate, 2,2'-bipyridine and Aqua Ligands: Synthesis, Crystal Structure and Investigation of Magnetic Properties.

A dinuclear copper(II) complex of formula [{Cu()()(OH)}(μ-)] () (where = 2,2'-bipyridine, = benzoate and = oxalate) was synthesised and characterised by diffractometric (powder and single-crystal XRD) and thermogravimetric (TG/DTG) analyses, spectroscopic techniques (IR, Raman, electron paramagnetic resonance spectroscopy (EPR) and electronic spectroscopy), magnetic measurements and density functional theory (DFT) calculations. The analysis of the crystal structure revealed that the oxalate ligand is in bis(bidentate) coordination mode between two copper(II) centres. The other four positions of the coordination environment of the copper(II) ion are occupied by one water molecule, a bidentate and a monodentate ligand.

Crystal structures of binuclear complexes of gadolinium(III) and dysprosium(III) with oxalate bridges and chelating ,'-bis-(2-oxido-benz-yl)-,'-bis-(pyridin-2-ylmeth-yl)ethyl-enedi-amine (bbpen).

The reaction between mononuclear [(bbpen)Cl] [ = Gd or Dy; Hbbpen = ,'-bis-(2-hy-droxy-benz-yl)-,'-bis-(pyridin-2-ylmeth-yl)ethyl-enedi-amine, CHNO] and potassium oxalate monohydrate in water/methanol produced the solvated centrosymmetric isostructural binuclear (μ-oxalato)bis-{[,'-bis-(2-oxidobenzyl-κ)-,'-bis-(pyridin-2-ylmethyl-κ)ethyl-enedi-amine-κ ,']dilanthanide(III)}-methanol-water (1/4/4) complexes, [ (CHNO)(CO)]·4CHOH·4HO, with lanthanide(III) = gadolinium(III) ( = Gd) and dysprosium(III) ( = Dy), in high yields ( 70%) directly from the reaction mixtures. In both complexes, the lanthanide ion is eight-coordinate and adopts a distorted square-anti-prismatic coordination environment. The triclinic ( ) unit cell contains one dimeric unit together with four water and four methanol mol-ecules; in the final structural model, two of each type of solvating mol-ecule refine well.

Effect of Different Tensoactives on the Morphology and Release Kinetics of PLA-b-PEG Microcapsules Loaded With the Natural Anticancer Compound Perillyl Alcohol.

Perillyl alcohol is a natural compound that has attracted a significant interest due to its potent antitumor activity. However, clinical trials have exhibited poor tolerance by oral administration, mainly due to gastrointestinal side effects. We propose the entrapment of perillyl alcohol into poly(D,L-lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG) as delivery platform (entrapment efficiency of 63%-68%).