Publications by authors named "Giorgos Tzanis"

Article Synopsis
  • This study aimed to assess the outcomes of patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) using the 34 mm Evolut R valve.
  • It was found that while this valve had a device success rate of 87.4%, it also led to a higher rate of permanent pacemaker implantation (22.4%) compared to other valve sizes.
  • Overall, the 34 mm Evolut R performed similarly to other valve sizes in terms of device success, indicating its effectiveness despite the increased pacemaker requirement.
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Article Synopsis
  • The study examined in-hospital mortality rates for patients undergoing percutaneous interventional procedures (PIP) during the COVID-19 pandemic compared to before the pandemic.
  • Researchers found a significant drop in the number of PIP performed (from 2380 to 1712), totaling a 28% reduction, while in-hospital mortality rates increased from 1.1% in 2019 to 2.6% in 2020.
  • The findings highlight that during the COVID-19 pandemic, there was a notable rise in all-cause mortality among patients undergoing cardiological PIP.
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Peripheral myopathy consists of a hallmark of heart failure (HF). Exercise enhanced skeletal muscle angiogenesis, and thus, it can be further beneficial towards the HF-induced myopathy. However, there is limited evidence regarding the exercise type that elicits optimum angiogenic responses of skeletal muscle in HF patients.

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Background: Horizontal aorta (HA) is an anatomical feature that can pose significant technical challenges for the successful positioning of the bioprosthetic valve during transcatheter aortic valve replacement (TAVR). Physiological range of aortic angle (AA) is unknown; hence there is no cutoff AA for classifying HA. Moreover, patient characteristics predicting HA are under-investigated.

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The coronary sinus reducer (CSR) has been introduced as therapy for patients with refractory angina with no other treatment options. Aim of this study is to investigate the efficacy of the CSR in patients with refractory angina and presence of coronary chronic total occlusions (CTO). In this multicentre, international retrospective study, patients undergoing CSR implantation were screened and divided in 2 groups according to the presence/absence of CTO lesions.

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Article Synopsis
  • The coronary sinus Reducer is a new treatment for patients with refractory angina, showing safety and clinical benefits.
  • It may improve blood flow to areas of the heart that are not getting enough oxygen, which could enhance heart function.
  • This case study supports further investigation of the Reducer in patients with ischemic heart disease and poor heart function.
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TAVR in bicuspid aortic valve (BAV) represents a challenging scenario. Valve sizing and positioning are the most important determinants of procedural success. In BAV the maximal prosthesis-anatomy interference occurs at the supra-annular level.

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Introduction: Coronary Sinus Reducer emerged as promising therapeutic option for patients with refractory angina. While recent literature reports short-term benefits of Reducer implantation, there is paucity of evidence regarding its safety and efficacy at longer follow-up.

Methods: In the original cohort of 50 refractory angina patients treated with Reducer at San Raffaele Hospital (Milan, Italy) between March 2015 and August 2016, we reassessed angina symptoms, quality of life and recorded adverse events at 2-year (mean ± SD: 748 ± 84 days) follow-up.

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Background: Vasopressin administration has been tested in cardiac arrest. However it has not been tested when cardiac arrest occurs in certain circumstances, as in sepsis, where it may have a major role. The aim of the study was to investigate survival after cardiac arrest in a septic porcine model compared with healthy animals and to explore the effectiveness of adding vasopressin vs epinephrine alone administration.

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Background: Patients with chronic heart failure (CHF) are characterized by exercise intolerance and ventilatory abnormalities that are related to poor prognosis. We hypothesized that CHF patients have increased respiratory drive and abnormal breathing pattern during exercise in relation to disease severity.

Materials And Methods: The study population consisted of 219 stable CHF patients and 30 healthy control subjects.

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