Publications by authors named "Giorgos Loucaides"
Article Synopsis
- A study found that a strict adherence to the Mediterranean diet is associated with a lower risk of breast cancer among Greek-Cypriot women, and certain genetic polymorphisms may influence this relationship.
- Researchers examined the interactions between genetic variations and the Mediterranean diet by measuring serum metabolites related to dietary habits and enzymatic activities in women with varying levels of diet adherence.
- Findings revealed significant interactions between specific genetic polymorphisms (GSTM1 deletion and MTHFR rs1801133) and dietary adherence, affecting concentrations of certain metabolites like flavin mononucleotide and 5-methyltetrahydrofolate.
Purpose: Xenobiotic metabolism is related to the interplay between diet and breast cancer (BC) risk. This involves detoxification enzymes, which are polymorphic and metabolise various dietary metabolites. An important characteristic of this pathway is that chemoprotective micronutrients can act not only as substrates but also as inducers for these enzymes.
View Article and Find Full Text PDFPurpose: Oxidative stress arises due to a cellular imbalance in oxidants and antioxidants and/or due to an altered activity of antioxidant enzymes, caused by SNPs. Oxidative stress increases susceptibility to breast cancer (BC) risk, and we previously showed that the Mediterranean diet (MD), which is rich in antioxidants, reduces BC risk in Greek-Cypriot women. Here, we investigated the effect of MnSOD (p.
View Article and Find Full Text PDFSingle-nucleotide polymorphisms (SNPs) within genes of the one-carbon metabolism pathway have been shown to interact with dietary folate intake to modify breast cancer (BC) risk. Our group has previously demonstrated that the Mediterranean dietary pattern, rich in beneficial one-carbon metabolism micronutrients, protects against BC in Greek-Cypriot women. We aimed to investigate whether SNPs in the MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) genes modify the effect of the Mediterranean dietary pattern on BC risk.
View Article and Find Full Text PDFBackground: Diet has long been suspected to impact on breast cancer risk. In this study we evaluated whether the degree of adherence to a Mediterranean diet pattern modifies breast cancer risk amongst Greek-Cypriot women.
Methods: Subjects included 935 cases and 817 controls, all participating in the MASTOS case-control study in Cyprus.