Publications by authors named "Giorgio Treglia"

Introduction: It has been reported that approximately 80-90% of apical prolapse repair is through reconstructive or obliterative vaginal surgery. Although several procedures have been described, to date there is a lack of consensus on the best surgical procedure. The aim of this study was to perform a thorough review of the current literature on the efficacy and safety of the iliococcygeus fixation technique for the treatment of vaginal vault prolapse.

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Recent research has proposed using positron emission tomography/computed tomography (PET/CT) along with the administration of prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals to identify breast cancer (BC) lesions. An extensive literature review to investigate the possible diagnostic utility of PET/CT with PSMA-targeting radiopharmaceuticals in BC patients was performed. The research comprised different clinical scenarios, including both newly diagnosed BC patients and those who had experienced disease relapse.

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  • Cardiac neuroendocrine tumour metastases (CNTM) are uncommon, but advances in SSTR-PET/CT imaging may help detect them more frequently, prompting this systematic review and meta-analysis.
  • A total of ten studies with 163 patients showed that SSTR-PET/CT detects CNTM earlier than other imaging methods, with a pooled prevalence of 1.5% among neuroendocrine neoplasm (NEN) patients undergoing the procedure.
  • The findings suggest that SSTR-PET/CT improves early detection of CNTM but indicate a need for more thorough studies to assess its effects on patient outcomes and treatment decisions in NEN cases.
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  • Radioligand therapy (RLT) with Lu-labelled prostate specific membrane antigen ([Lu]Lu-PSMA-X) is showing promise as a treatment for metastatic castration-resistant prostate cancer (mCRPC), especially for those who haven't received taxane chemotherapy.
  • This study conducted a systematic review and meta-analysis to compare the efficacy of [Lu]Lu-PSMA-X to traditional taxane chemotherapy in patients who haven't been treated with taxane.
  • The results indicated that both treatment groups had similar rates of prostate specific antigen (PSA) response, suggesting that [Lu]Lu-PSMA-X could be a viable option for mCRPC patients who are taxane-naïve.
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Infective endocarditis and infection of cardiac devices are conditions characterized by high morbidity and mortality, thus requiring a prompt diagnosis. Advanced imaging modalities are often required in the management of infectious endocarditis according to guidelines. The aim of this review is to collect and describe evidence-based knowledge about the diagnostic role and clinical usefulness of [F]FDG PET/CT in endocarditis and cardiac device infections based on published systematic reviews and meta-analyses on this topic and on recent guidelines.

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  • - Hybrid [F]FDG PET imaging is the preferred method for diagnosing infectious and inflammatory disorders, with recent updates in clinical guidelines reflecting a surge in evidence-based research since 2013.
  • - The aim of the updated guidelines is to furnish physicians with current, evidence-based knowledge to effectively conduct and interpret hybrid [F]FDG PET scans in adult patients.
  • - A systematic literature review revealed that hybrid [F]FDG PET is highly effective for managing these conditions, although monitoring treatment response remains a challenging area due to limited research.
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  • A study evaluated the effectiveness of a diagnostic strategy combining [F]Fluorocholine PET/CT with 4D-CT for patients with primary hyperparathyroidism (pHPT) undergoing surgery.
  • The results showed that PET/CT was significantly more accurate than 4D-CT, with high sensitivity and specificity rates (83% and 97%, respectively), whereas 4D-CT had lower rates (53% sensitivity).
  • When PET/CT results were inconclusive, using the two imaging methods together improved diagnostic accuracy, making it a recommended personalized imaging approach for pHPT patients.
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Purpose: This updated systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[F]FDG PET/CT for the detection of recurrent disease in patients with differentiated thyroid cancer (DTC) who have negative I whole body scintigraphy and increased antithyroglobulin antibodies (TgAb) levels.

Methods: The current systematic review was carried out following a preset protocol, and the "Preferred Reporting Items for a Systematic Review and Meta-Analysis" served as a guideline for its development and reporting. A comprehensive research of the PubMed/MEDLINE, Embase and Cochrane library databases was conducted until June 2024.

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  • - The study evaluated the prognostic value of baseline and post-treatment [18F]FDG PET/CT scans in patients with oropharynx cancer (OPC) undergoing chemotherapy and/or radiotherapy.
  • - Researchers analyzed PET/CT data from 66 patients and found that volumetric parameters significantly predicted overall survival (OS) and were useful for predicting progression-free survival (PFS) at restaging.
  • - No notable relationship was found between human papillomavirus (HPV) infection and PET/CT results, highlighting the importance of imaging parameters in assessing OPC prognosis.
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Background: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([F]FDG PET/CT) has been suggested as a useful imaging method for diagnosing cyst infections in patients with autosomal dominant polycystic kidney disease (ADPKD). The aim of this article is to provide evidence-based data in this setting.

Methods: A systematic literature review (exploring several bibliographic databases) and a bivariate meta-analysis were carried out to calculate the pooled diagnostic performance of [F]FDG PET/CT in diagnosing probable cyst infection in ADPKD.

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Here, we describe the case of a 43-year-old male patient with a metastatic parathyroid carcinoma who underwent dual-tracer whole-body positron emission tomography/computed tomography (PET/CT) with [F]fluorocholine and fluorodeoxyglucose ([F]FDG) for staging. [F]FDG PET/CT detected multiple cervical and mediastinal lymph nodal lesions with increased tracer uptake, whereas [F]fluorocholine PET/CT detected increased tracer uptake on cervical and mediastinal lymph nodal lesions and bone and lung lesions with a better evaluation of metastatic spread. Due to these imaging findings, the patient underwent systemic treatment with chemotherapy.

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Background: Recent studies have suggested using positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for the detection of salivary gland malignancies (SGM), particularly adenoid-cystic carcinoma (ACC).

Methods: The authors conducted an extensive review of the scientific literature to examine the potential diagnostic role of PET/CT using PSMA-targeting radiopharmaceuticals in salivary gland malignancies (SGMs) and adenoid cystic carcinoma (ACC). This study included newly diagnosed SGM patients and those with disease recurrence in their imaging evaluation.

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Molecular imaging of muscle-invasive bladder cancer (MBC) is restricted to its locoregional and distant metastases, since most radiopharmaceuticals have a urinary excretion that limits the visualization of the primary tumor. CuCl a positron-emitting radiotracer with nearly exclusive biliary elimination, could be well suited to exploring urinary tract neoplasms. In this study, we evaluated the feasibility of CuCl-based staging of patients with MBC; furthermore, we compared the diagnostic capability of this method with those of the current gold standards, that is, contrast-enhanced CT (ceCT) and F-FDG PET/CT.

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  • The study investigates thyroid nodules (AFTNs) and the use of the TIRADS system to prevent unnecessary fine-needle aspiration cytologies (FNACs).
  • It found that only 37.5% of AFTNs had FNAC indications according to TIRADS, with low TSH levels and larger nodule size being significant predictors of unnecessary procedures.
  • The conclusion emphasizes that the risk of unnecessary FNACs is low for AFTNs undergoing scintigraphy, suggesting no need for additional imaging in the TIRADS framework.
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The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the literature is still in its initial phases. We conducted a systematic search of Scopus, PubMed/MEDLINE, Embase, and Cochrane library databases for studies published before 31 December 2023 reporting infectious and inflammatory disease imaging with FAPI PET/CT. We included twenty-one studies for a total of 1046 patients.

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Introduction: A physiological increase in the uptake of [Ga]Ga-labeled somatostatin analogues ([Ga]Ga-SST) PET tracers has been reported in the uncinate pancreatic process (UP) and might be even higher in latest generation of PET/CT scanners and might be falsely interpreted as NET. We aimed to investigate the uptake of UP in a large population of NET patients who underwent [Ga]Ga-SST PET/CT with digital SiPM detectors. We also explored potential associations between UP uptake and various clinical, imaging, and pathological factors routinely assessed in NET patients.

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Purpose: Prostate-Specific Membrane Antigen (PSMA)-targeted Positron Emission Tomography (PET) has revolutionised prostate cancer (PCa) diagnosis and treatment, offering superior diagnostic accuracy over traditional methods and enabling theragnostic applications. However, a significant diagnostic challenge has emerged with identifying unspecific bone uptakes (UBUs), which could lead to over-staging and inappropriate treatment decisions if misinterpreted. This systematic review explores the phenomenon of UBUs in PCa patients undergoing PSMA-PET imaging.

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