New relative sea-level (RSL) indications from the Eastern Mediterranean: Middle Bronze Age to the Roman period (~3800-1800 y BP) archaeological constructions at Dor, the Carmel coast, Israel.

This article presents new archaeological observations and multidisciplinary research from Dor, Israel to establish a more reliable relative sea level for the Carmel Coast and Southern Levant between the Middle Bronze Age and the Roman period (ca. 3500-1800 y BP). Our record indicates a period of low relative sea level, around -2.

Local sea level trends, accelerations and uncertainties over 1993-2019.

Satellite altimetry missions provide a quasi-global synoptic view of sea level variations over more than 25 years and provide regional sea level (SL) indicators such as trends and accelerations. Estimating realistic uncertainties on these quantities is crucial to address current climate science questions. While uncertainty estimates are available for the global mean sea level (GMSL), information is not available at local scales so far.

Post-LGM coastline evolution of the NW Sicilian Channel: Comparing high-resolution geophysical data with Glacial Isostatic Adjustment modeling.

Since about 20,000 years ago, the geography of the Earth has been profoundly modified by the gradual sea-level rise caused by the melting of continental ice sheets. Flat areas and regions characterized by very low gradients experienced, more than others, rapid flooding, with the progressive disappearance of vast coastal territories. Here we present a reconstruction of the late Quaternary coastline evolution of the north-western sector of the Sicilian Channel, constrained by high-resolution seismic profiles where the marker of the post-Last Glacial Maximum (LGM) marine transgression has been clearly identified and mapped.

Paleofluvial mega-canyon beneath the central Greenland ice sheet.

Subglacial topography plays an important role in modulating the distribution and flow of basal water. Where topography predates ice sheet inception, it can also reveal insights into former tectonic and geomorphological processes. Although such associations are known in Antarctica, little consideration has been given to them in Greenland, partly because much of the ice sheet bed is thought to be relatively flat and smooth.

Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment.

Disorders of human communication abilities can be classified into speech and language disorders. Speech disorders (e.g.

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling.

In order to identify new markers of vascular cell senescence with potential in vivo implications, primary cultured endothelial cells, including human umbilical vein endothelial cells (HUVECs), human aortic endothelial cells (HAECs), human coronary artery endothelial cells (HCAECs) and ex vivo circulating angiogenic cells (CACs), were analysed for microRNA (miR) expression. Among the 367 profiled miRs in HUVECs, miR-146a, miR-9, miR-204 and miR-367 showed the highest up-regulation in senescent cells. Their predicted target genes belong to nine common pathways, including Toll-like receptor signalling (TLR) that plays a pivotal role in inflammatory response, a key feature of senescence (inflammaging).

Predicting microRNA modulation in human prostate cancer using a simple String IDentifier (SID1.0).

To make faster and efficient the identification of mRNA targets common to more than one miRNA, and to identify new miRNAs modulated in specific pathways, a computer program identified as SID1.0 (simple String IDentifier) was developed and successfully applied in the identification of deregulated miRNAs in prostate cancer cells. This computationally inexpensive Fortran program is based on the strategy of exhaustive search and specifically designed to screen shared data (target genes, miRNAs and pathways) available from PicTar and DIANA-MicroT 3.