Publications by authors named "Giorgio Maria Biasi"
Objective: The aim of the present study was to comprehensively evaluate systemic and local inflammation as well as progression of vascular inflammation in normal and mechanically injured vessels in a large animal model of mild hypercholesterolemia. Our aim was also to test the effect of high-dose statin treatment on these processes.
Methods: Pigs were kept for 120 days on a standard diet (SD, n=7), high-cholesterol diet (HCD, n=7) or high-cholesterol diet with Atorvastatin starting after 50 days (STATIN, n=7).
Article Synopsis
- Scientists are studying how two proteins, HO-1 and iNOS, affect blood vessel diseases, particularly focusing on what happens when blood vessel cells are injured.
- They discovered that nitric oxide (NO), produced by iNOS, can stop blood vessel cells from growing too much, but needs HO-1 to do this effectively.
- Additionally, in cells without HO-1, NO leads to even more cell death, suggesting HO-1 helps protect these cells while also having an important role in reducing extra growth.
Article Synopsis
- Researchers created a pig model that mimics human blood vessel narrowing (stenosis) caused by high cholesterol levels to study its effects.
- They fed pigs different diets and caused injuries to their carotid arteries, finding that high cholesterol led to more significant blood vessel narrowing and inflammation.
- This study helps understand how high cholesterol affects blood vessels and could lead to new treatments to prevent narrowing in humans.