Publications by authors named "Giorgio M Melloni"
Article Synopsis
- Interest in targeted screening for atrial fibrillation (AF) is rising, but the impact of genetics on identifying at-risk patients is still uncertain.
- A study involving over 36,000 participants revealed that a polygenic risk score (PRS) significantly predicts AF risk, with those in the top 20% of PRS being more than twice as likely to develop AF compared to those in the bottom 20%.
- The PRS enhances risk stratification beyond traditional clinical models, increasing prediction accuracy of AF events when combined with other factors like NT-proBNP.
Background: Genome-wide association studies have identified single-nucleotide polymorphisms that are associated with an increased risk of stroke. We sought to determine whether a genetic risk score (GRS) could identify subjects at higher risk for ischemic stroke after accounting for traditional clinical risk factors in 5 trials across the spectrum of cardiometabolic disease.
Methods: Subjects who had consented for genetic testing and who were of European ancestry from the ENGAGE AF-TIMI 48 (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation), SOLID-TIMI 52 (Stabilization of Plaques Using Darapladib), SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus), PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin), and FOURIER (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Patients With Elevated Risk) trials were included in this analysis.