Publications by authors named "Giorgio M Biasi"
Objective: The aim of the present study was to comprehensively evaluate systemic and local inflammation as well as progression of vascular inflammation in normal and mechanically injured vessels in a large animal model of mild hypercholesterolemia. Our aim was also to test the effect of high-dose statin treatment on these processes.
Methods: Pigs were kept for 120 days on a standard diet (SD, n=7), high-cholesterol diet (HCD, n=7) or high-cholesterol diet with Atorvastatin starting after 50 days (STATIN, n=7).
Article Synopsis
- Scientists are studying how two proteins, HO-1 and iNOS, affect blood vessel diseases, particularly focusing on what happens when blood vessel cells are injured.
- They discovered that nitric oxide (NO), produced by iNOS, can stop blood vessel cells from growing too much, but needs HO-1 to do this effectively.
- Additionally, in cells without HO-1, NO leads to even more cell death, suggesting HO-1 helps protect these cells while also having an important role in reducing extra growth.
Article Synopsis
- Researchers created a pig model that mimics human blood vessel narrowing (stenosis) caused by high cholesterol levels to study its effects.
- They fed pigs different diets and caused injuries to their carotid arteries, finding that high cholesterol led to more significant blood vessel narrowing and inflammation.
- This study helps understand how high cholesterol affects blood vessels and could lead to new treatments to prevent narrowing in humans.
The Registro Italiano per lo Stenting Carotideo (RISC, Italian Registry for Carotid Stenting) has been organized by Italian specialists from different disciplines directly involved in the prevention of stroke due to carotid plaques through stenting of carotid lesions. The Registry has been endorsed by the national societies of 4 different specialties: vascular surgery, interventional cardiology, radiology, and neuroradiology. Each society contributed in the planning stage.
View Article and Find Full Text PDFBackground: Carotid artery stenting (CAS) has recently emerged as a potential alternative to carotid endarterectomy. Cerebral embolization is the most devastating complication of CAS, and the echogenicity of carotid plaque has been indicated as one of the risk factors involved. This is the first study to analyze the role of a computer-assisted highly reproducible index of echogenicity, namely the gray-scale median (GSM), on the risk of stroke during CAS.
View Article and Find Full Text PDFCarotid artery stenting (CAS) is used widely to treat carotid lesions. Indication to CAS is mostly based, both in trial and in clinical practice, on the percentage of stenosis and the presence or absence of preprocedural neurologic symptoms, whereas the features of the plaque are somehow disregarded and ignored. The most severe complication of CAS is stroke, related to cerebral embolization from carotid plaque.
View Article and Find Full Text PDFPurpose: This paper examines the clinical results of a 9-year experience in which the incidence of major (stroke and death) perioperative events and of recurrent stenosis (>60%) after carotid endarterectomy performed with a direct suture (DS) of the arteriotomy versus bovine pericardium patch angioplasty (BPPA) are compared.
Methods And Materials: A total of 517 carotid endarterectomies were included in this nonrandomized study and were divided into two groups: group DS with 194 procedures and group BPPA with 323 procedures. All patients were entered in a follow-up program that ranged from 1 to 108 months (mean, 56.
Purpose: To describe a case of improved renal function and renovascular hypertension after percutaneous treatment of a renal artery aneurysm.
Case Report: A 72-year-old hypertensive woman with a hilar saccular aneurysm of the right renal artery underwent percutaneous coil embolization under local anesthesia. Four individual, soft, detachable platinum embolization coils were successfully inserted in the aneurysm with incomplete aneurysm exclusion.