Synopsis of recent research by authors named "Giorgio Lagna"
- Giorgio Lagna's recent research focuses on the mechanisms of pulmonary veno-occlusive disease (PVOD), investigating how age and specific chemotherapy agents like mitomycin C (MMC) exacerbate this condition by activating stress response pathways and altering vascular integrity.
- His studies reveal that the integrated stress response, notably through the action of protein kinase R (PKR), contributes to the pathological release of endothelial adhesion molecules and vascular remodeling in PVOD, potentially offering insights into new therapeutic approaches.
- Additionally, Lagna's work on the Drosha enzyme highlights its critical role in microRNA processing and vascular homeostasis, with implications for hereditary diseases such as hereditary hemorrhagic telangiectasia, thereby linking microRNA regulation to vascular pathology.
