Publications by authors named "Giorgio Gandolini"

Background: Low back pain (LBP) is one of the most frequent diseases for which patients seek advice in a community pharmacy. The study aimed to evaluate the feasibility of the administration by community pharmacists of questionnaires to assess the LBP intensity and disability degree in patients entering community pharmacies and the attitudes they have toward pain management by pharmacological and non-pharmacological strategies.

Methods: An explorative, cross-sectional, observational, and quantitative study was performed.

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Objectives: Aging might affect the effectiveness of the sole supplementation of calcium and vitamin D in post-menopausal women, due to the development of vitamin D resistance in the gut, which limits calcium absorption. Thus, we wanted to test the efficacy of a mixture of calcium (500 mg), 25-hydroxyvitamin D [25(OH)D; 300 IU], inulin (3 g) and soy isoflavones (40 mg), to improve calcium absorption in this type of population.

Study Design: It is a retrospective study on otherwise healthy post-menopausal women.

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Article Synopsis
  • The study compares the effectiveness of Artificial Neural Networks (ANNs) and Logistic Regression (LR) in predicting osteoporotic fractures (OF) based on spinal deformity index (SDI) in postmenopausal women.
  • ANNs significantly outperformed LR in both sensitivity and accuracy when identifying patients with varying degrees of SDI, indicating a potential for better predictive algorithms.
  • The findings suggest that ANNs could be a valuable tool in improving fracture risk assessments, showing promise for future use in clinical settings.
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A positive history of fractures in older patients with hip fracture is common. We determined the risk factors associated with a positive history of fractures and the profile of care in hip fracture patients. In the Break Study, we enrolled 1249 women aged ≥60 years, seeking care for a hip fracture.

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Background: Vitamin D deficiency is very common in elderly people while there are very few reports on its incidence, determinants and metabolic consequences in young subjects.

Results: In 608 young healthy premenopausal women participating in the BONTURNO study, levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/ml were found in almost a third of the women. Its levels were inversely (P<0.

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Absorptive hypercalciuria (AH) is associated with elevated levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D). While no increase of 1,25(OH)(2)D after oral administration of 25-hydroxyvitamin D (25OHD) at high doses has been claimed in normal subjects, a substrate-product relationship has been reported in normal children, young people after UV irradiation, older persons, postmenopausal women, primary hyperparathyroidism, renal failure, osteomalacia, and sarcoidosis. No data of this relationship in AH is available.

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