Publications by authors named "Giorgio Capizzi"

Slow biphasic complexes (SBC) have been identified in the EEG of patients suffering for inflammatory brain diseases. Their amplitude, location and frequency of appearance were found to correlate with the severity of encephalitis. Other characteristics of SBCs and of EEG traces of patients could reflect the grade of pathology.

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We report the management of refractory status epilepticus (SE) by using continuous intravenous infusions of lidocaine in a previously healthy 15-year-old girl with a "catastrophic encephalopathy" in whom a diagnosis of febrile infection-related epilepsy syndrome was supposed. One week after a banal pharyngitis and fever, the patient presented confusion and intractable clusters of seizures. Although she underwent multiple examinations investigating all possible etiologies (intracranial infection, autoimmune disease, or toxic and metabolic illness), all results were negative except a feeble positivity to Mycoplasma pneumoniae serum antibodies.

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Article Synopsis
  • Researchers sequenced the KCNT1, PLCB1, SCN1A, and TBC1D24 genes in six children showing symptoms of malignant migrating partial seizures of infancy (MMPSI) to look for disease-causing mutations.
  • Sanger sequencing did not reveal the previously known mutations, but targeted re-sequencing uncovered new variants in both intronic and exonic regions of the genes.
  • The new genetic variants found do not currently provide insights into their potential impact on MMPSI symptoms, leaving the cause of the condition unclear.
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Rolandic epilepsy (RE) is the most common childhood epilepsy syndrome with a good, long-term outcome. Nevertheless, some studies indicate that children with RE have more scholastic and neuropsychological problems than controls. The purpose of this study was to describe neuropsychological findings in a small group of Italian children with RE, focusing on dyslexia and dyscalculia.

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