Pulmonary hypertension in patients with Sjögren's syndrome: Gender differences in cardiovascular risk factors and instrumental data.

Background: Pulmonary hypertension (pH) is a well-documented complication in patients with connective tissue diseases, including Sjögren's syndrome (SS). However, the prevalence of PH in SS varies considerably across studies, likely due to differences in diagnostic methods.

Aim Of The Study: This study aims to assess the prevalence of PH in a cohort of SS patients and to examine potential differences in age, cardiovascular risk factors, autoimmunity, pulmonary function tests, and echocardiographic parameters between male and female SS patients.

Increase of circulating cell free mitochondrial DNA in amateur boxers after sparring matches.

Objectives: To determine if circulating mitochondrial deoxyribonucleic acid levels increase after sport activity involving blows to the head, such as boxing, and if it could play a role in inflammatory cascade regulation in response to trauma.

Design: Observational, longitudinal.

Methods: We measured mitochondrial deoxyribonucleic acid levels and integrity in ten non-professional male boxers before and after three weekly sparring matches.

Sex Related Differences in the Complex Relationship between Coffee, Caffeine and Atrial Fibrillation.

This literature review aims to explore the data of articles published on the association between coffee, caffeine and atrial fibrillation and to analyze any differences between the two sexes. Several factors influence this complex relationship; genetic, environmental and psychosocial factors come into play in the pathophysiology of atrial fibrillation. These factors are expressed differently in women and men.

The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases.

The mitochondrial protease Lonp1 is a multifunctional enzyme that regulates crucial mitochondrial functions, including the degradation of oxidized proteins, folding of imported proteins and maintenance the correct number of copies of mitochondrial DNA. A series of recent studies has put Lonp1 at the center of the stage in the homeostasis of cardiomyocytes and muscle skeletal cells. During heart development, Lonp1 allows the metabolic shift from anaerobic glycolysis to mitochondrial oxidative phosphorylation.