Publications by authors named "Giorgia Di Filippo"
Aims: Yolk sac tumour postpubertal-type (YSTpt) shows a wide range of histological patterns and is challenging to diagnose. Recently, forkhead box transcription factor A2 (FoxA2) emerged as a driver of YSTpt formation and a promising marker for diagnosing YSTpt. However, FoxA2 has not been tested in the different patterns of YSTpt.
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- A study examined cutaneous melanoma (CM) cases with unusual overexpression of p16, which usually indicates loss of function, focusing on their clinicopathological characteristics and molecular mutations.
- Out of 2,879 CM cases analyzed, only 10 showed p16 overexpression, categorized into three groups based on the presence of mutations in key genes like TP53 and changes in cell cycle regulatory molecules.
- The findings suggest that p16 overexpression can occur in CM, indicating a potentially unique biological behavior and differing pathways from classic melanoma, highlighting the complexity of tumor genetics.
Background: In recent years, several studies focused on the process of reprogramming of seminoma (S) cells, which regulates the transition from pure S (P-S) to S component (S-C) of mixed germ cell tumors of the testis (GCTT) and finally to embryonal carcinoma (EC) and other nonseminomatous GCTT (NS-GCTT). The accepted pathogenetic model is driven and regulated by cells (macrophages, B- and T-lymphocytes) and molecules of the tumor microenvironment (TME). Herein, we tested a series of GCTT with double staining (DS) for CD68-PD-L1 to evaluate tumor-associated macrophages (TAMs) expressing programmed death-ligand 1 (PD-L1) [TAMs PD-L1(+)] and clarify if these cells may be involved in establishing the fate of GCTT.
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