Publications by authors named "Giorgia Codispoti"
Article Synopsis
- The study addresses the need for better in vitro methods to explore the potential of smart biomaterials in prosthetic surgery, focusing on osteointegration before moving to in vivo tests.
- Researchers created an innovative tissue culture model using human trabecular bone with different groups of cylindrical defects—some empty, some filled with harmful copper pins, and others with standard titanium pins.
- Results showed that titanium pins had a positive effect on bone viability and growth, whereas the copper pins were detrimental, indicating that the model effectively mimics the osteointegration process and could help reduce reliance on animal testing.
Rotator cuff tears (RCTs), resulting from degeneration or trauma of the shoulder tendons, are one of the main causes of shoulder pain. In particular, massive RCTs represent 40% of all injuries, require surgical treatment, and are characterized by poor clinical outcomes and a high rate of failure. In recent years, the use of biological decellularized patches for augmentation procedures has received great interest owing to their excellent self-integration properties, improving healing and, thus, presenting an innovative therapeutic option.
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- Scientists are exploring how piezoelectric nanomaterials and ultrasound can help repair tissues, and they found it might work well for creating cartilage.
- In their study, they used special tiny particles mixed in a gel and applied exact ultrasound settings, which helped certain cells turn into cartilage cells even better.
- They also created a model to predict how electricity from the ultrasound affects the materials at a tiny level, and the gel they used was safe and stuck well to cartilage, showing promise for future tests.
Osteoarthritis (OA) is a severe musculoskeletal disease with an increasing incidence in the worldwide population. Recent research has focused on the development of innovative strategies to prevent articular cartilage damage and slow down OA progression, and nanotechnologies applied to hydrogels have gained particular interest. The aim of this systematic review is to investigate the state of the art on preclinical in vitro and in vivo efficacy studies applying nanotechnologies to hydrogels in OA models to elucidate the benefits of their applications.
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