Publications by authors named "Ginther Andre"
Objective: Myocardial protection is important for a successful procedure cardiac surgery, and the key element of myocardial protection is cardioplegia. We compared Del Nido cardioplegia (DN) and Bretschneider histidine-tryptophan-ketoglutarate cardioplegia (HTK) regarding cardioprotective effects in a porcine model of prolonged ischaemia.
Methods: Landrace pigs weighing 50-60 kg were randomized to receive either DN ( = 9) or HTK ( = 9).
Objectives: In this study, we evaluated if modified Del Nido cardioplegia delivers comparable cardiac protection in comparison to Custodiol® in patients undergoing isolated minimally invasive mitral valve repair.
Methods: From January 2018 to October 2021, all patients undergoing non-emergent isolated minimally invasive mitral valve repair were included in this study. The cardioplegia was chosen at the surgeons' discretion.
Article Synopsis
- The study analyzes outcomes of patients with normal left ventricular ejection fraction (LVEF) who needed venoarterial extracorporeal membrane oxygenation (VA-ECMO) due to postcardiotomy cardiogenic shock (PCCS) from coronary issues.
- It is based on a retrospective analysis of 59 patients treated between May 1998 and May 2018, revealing a high 30-day mortality rate of 50.8% and notable complications in most patients.
- Key predictors of mortality include high lactate levels before VA-ECMO, delays in revascularization, and the presence of peripheral arterial disease, suggesting that timely intervention is critical for improving survival chances.
Cardioplegic solutions play a major role in cardiac surgery due to the fact that they create a silent operating field and protect the myocardium against ischemia and reperfusion injury. For studies on cardioplegic solutions, it is important to compare their effects and to have a valid platform for preclinical testing of new cardioplegic solutions and their additives. Due to the strong anatomical and physiological cardiovascular similarities between pigs and humans, porcine models are suitable for investigating the effects of cardioplegic solutions.
View Article and Find Full Text PDFObjectives: Assessment of early outcomes in patients with normal preoperative left ventricular ejection fraction (LVEF) in whom venoarterial extracorporeal membrane oxygenation (VA-ECMO) was implanted for postcardiotomy cardiogenic shock (PCCS) during the first postoperative 48 h.
Methods: Retrospective single-centre analysis in adult patients with normal LVEF, who received VA-ECMO support for PCCS from May 1998 to May 2018. The primary outcome was 30-day perioperative mortality during the index hospitalization.