Publications by authors named "Gino Girardi"
Article Synopsis
- Ventilator-associated bacterial pneumonia (VABP) presents a challenging treatment dilemma, with ongoing debates about the best antibiotic approach and recent guidelines recommending a 7-day course due to benefits like reduced mortality and resistance.
- The study focuses on measuring the bacterial load in patients suspected of having VABP by analyzing bronchoalveolar lavage (BAL) fluid and calculating a dilution factor to estimate the true bacterial burden.
- Findings reveal a median dilution factor of 28.7, indicating significant bacterial counts that could influence treatment efficacy, particularly as high bacterial loads can hinder the effectiveness of the immune response.
Synthetic thymosin beta 4 (Tbeta4) may have a potential use in promoting myocardial cell survival during acute myocardial infarction. Four cohorts, with 10 healthy subjects each, were given a single intravenous dose of placebo or synthetic Tbeta4. Cohorts received ascending doses of either 42, 140, 420, or 1260 mg.
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