Publications by authors named "Ginji Komiya"
Tau aggregation is a defining feature of neurodegenerative tauopathies, including Alzheimer's disease, corticobasal degeneration, and frontotemporal dementia. This aggregation involves the liquid-liquid phase separation (LLPS) of Tau, followed by its sol-gel phase transition, representing a crucial step in aggregate formation both in vitro and in vivo. However, the precise cofactors influencing Tau phase transition and aggregation under physiological conditions (e.
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- Synucleinopathies, like Parkinson's disease and dementia with Lewy bodies, are caused by the clumping of α-synuclein proteins, leading to nerve cell damage, but the exact mechanism behind this aggregation is still unclear.
- The study shows that RNA G-quadruplexes form structures that promote α-synuclein aggregation, especially when calcium levels in the cell rise, accelerating the transition from a soluble to a gel-like state of the protein.
- Using a light-controlled method to induce RNA G-quadruplex formation increases α-synuclein aggregation and neuronal dysfunction, but treating with 5-aminolevulinic acid can prevent this phase separation, reducing protein clumping and related motor