Publications by authors named "Ginger Kinch"

Article Synopsis
  • Neuronal death during development can be regulated by steroid hormones, with specific motoneurons in the hawkmoth Manduca sexta undergoing programmed cell death (PCD) in a segment-specific manner triggered by the hormone 20-hydroxyecdysone (20E).
  • APR motoneurons in abdominal segment six (APR(6)) die shortly after pupal ecdysis, while those in segment four (APR(4)) survive into adulthood, highlighting the role of intrinsic segmental identity in PCD outcomes.
  • Investigations showed that the death of APR(6) is characterized by autophagic features, mitochondrial dysfunction, and DNA fragmentation, emphasizing the distinct cellular mechanisms involved in steroid-induced motoneuron death.
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