Publications by authors named "Ginez A Gonzalez Martinez"
Article Synopsis
- Understanding how platelets influence oligodendrocyte progenitor cell (OPC) function is crucial for developing treatments for multiple sclerosis (MS).
- Research shows that platelets aggregate near OPCs in demyelinated areas, and reducing platelets leads to impaired OPC differentiation and remyelination.
- The study indicates that platelets have a dual role in remyelination, enhancing OPC differentiation initially but suppressing it with prolonged exposure, providing insights into remyelination challenges in MS.
Remyelination is the regeneration of myelin sheaths following demyelination. This regenerative process is critical for the re-establishment of axonal conduction velocity and metabolic support to the axons. Successful remyelination in the CNS generally depends on the activation, proliferation, and differentiation of oligodendrocyte progenitor cells (OPCs).
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