Publications by authors named "Ginerete R"
Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation. mGlu3 mice showed an enhanced nigro-striatal damage and microglial activation in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
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- The study highlights the role of mGlu5 receptors in various forms of monogenic autism, building on previous findings related to fragile-X syndrome (FXS).
- Researchers developed a method to assess a specific signaling pathway (PI hydrolysis) in mice models of autism, discovering that this pathway was significantly reduced in key brain regions of mice with Angelman syndrome (AS) and FXS.
- The findings suggest that the typical signaling process linked to mGlu5 receptors is impaired in these autism models, marking a significant advancement in understanding the neurobiological aspects of monogenic autism.
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- Dkk3 (Dickkopf-3) is a protein that influences blood pressure regulation and is linked to hypertension in rats; its full role in cardiovascular health remains unclear.* -
- Research using genetically modified mice and hypertensive rat models showed that deleting Dkk3 increased blood pressure and impaired blood vessel relaxation, but restoring Dkk3 countered these effects.* -
- The protein functions by enhancing VEGF (vascular endothelial growth factor) expression and activating a signaling pathway that lowers blood pressure, highlighting Dkk3’s potential as a therapeutic target for hypertension.*
The epigenetic agents, L-acetylcarnitine (LAC) and L-methylfolate (MF) are putative candidates as add-on drugs in depression. We evaluated the effect of a combined treatment with LAC and MF in two different paradigms of chronic stress in mice and in human inducible pluripotent stem cells (hiPSCs) differentiated into dopaminergic neurons. Two groups of mice were exposed to chronic unpredictable stress (CUS) for 28 days or chronic restraint stress (CRS) for 21 day, and LAC (30 or 100 mg/kg) and/or MF (0.
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- Pilots and flight crew experience brief periods of reduced oxygen levels daily, which may affect their performance over time.
- In a study with mice, brief mild oxygen reductions were applied for 21 days along with chronic stress to observe effects on behavior and brain function.
- The results indicated that these oxygen reductions improved mood, reduced anxiety, and enhanced learning in stressed mice, whereas they had minimal impact on unstressed mice.
Group II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors) shape mechanisms of methamphetamine addiction, but the individual role played by the two subtypes is unclear. We measured methamphetamine-induced conditioned place preference (CPP) and motor responses to single or repeated injections of methamphetamine in wild-type, mGlu2, and mGlu3mice. Only mGlu3mice showed methamphetamine preference in the CPP test.
View Article and Find Full Text PDFInterkingdom communication between bacteria and host organisms is one of the most interesting research topics in biology. Quorum sensing molecules produced by Gram-negative bacteria, such as acylated homoserine lactones and quinolones, have been shown to interact with host cell receptors, stimulating innate immunity and bacterial clearance. To our knowledge, there is no evidence that these molecules influence CNS function.
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