A postmortem high-resolution MRI study of the development of cochlear nerve-related structures in the second and third trimesters of pregnancy.

Background: Magnetic resonance imaging (MRI) is used to determine whether cochlear nerve development is normal in infants and adults, but it has not yet been used to evaluate cochlear nerve development or measure cochlear nerve-related structures in the fetus. This study sought to provide imaging data for clinical evaluations concerning cochlear nerve development in the fetus using MRI.

Methods: Postmortem 3.

Emerging Head and Neck Tumor Targeting Contrast Agents for the Purpose of CT, MRI, and Multimodal Diagnostic Imaging: A Molecular Review.

Background: The diagnosis and treatment of head and neck tumors present significant challenges due to their infiltrative nature and diagnostic hindrances such as the blood-brain barrier. The intricate anatomy of the head and neck region also complicates the clear identification of tumor boundaries and assessment of tumor characteristics.

Aim: This review aims to explore the efficacy of molecular imaging techniques that employ targeted contrast agents in head and neck cancer imaging.

Switching anti-EGFR antibody re-sensitizes head and neck cancer patient following acquired resistance to cetuximab.

Cetuximab induces responses in about 13% of head and neck squamous cell carcinomas (HNSCC). We describe the molecular mechanism of acquired resistance to cetuximab, which could be overcome by switching to a different anti-EGFR antibody. Biopsies were collected at three different time points: before the start of cetuximab (PRE-cetux), at acquired resistance to cetuximab (AR-cetux), and at acquired resistance to duligotuzumab (AR-duligo).

Neoadjuvant Nivolumab Plus Chemotherapy Followed By Response-Adaptive Therapy for HPV+ Oropharyngeal Cancer: OPTIMA II Phase 2 Open-Label Nonrandomized Controlled Trial.

Importance: Immune checkpoint inhibitors improve survival in recurrent and/or metastatic head and neck cancer, yet their role in curative human papillomavirus-positive oropharyngeal cancer (HPV+ OPC) remains undefined. Neoadjuvant nivolumab and chemotherapy followed by response-adaptive treatment in HPV+ OPC may increase efficacy while reducing toxicity.

Objective: To determine the deep response rate and tolerability of the addition of neoadjuvant nivolumab to chemotherapy followed by response-adapted locoregional therapy (LRT) in patients with HPV+ OPC.

Imaging features and surgical management of giant parathyroid adenoma with autoinfarction.

Autoinfarction of a parathyroid adenoma can have an atypical clinicoradiologic features that can mimic an inflammatory process or malignancy. In addition, the associated fibrosis makes surgical resection more challenging than for regular parathyroid adenomas. The implications of these findings are that while autoinfarction of parathyroid adenomas is a rare phenomenon, this entity should be considered when there are heterogeneous and cystic components on imaging in patients without hypercalcemia.

Early Postoperative Magnetic Resonance Imaging Findings Related to Electrocauterization for Cerebellar Reduction During Chiari Decompression Surgery.

Background: Cerebellar tonsillar reduction or resection can be performed as part of the surgical management of Chiari type 1 malformation when it is accompanied by symptomatic brainstem compression or syringomyelia. The purpose of this study is to characterize the early postoperative magnetic resonance imaging (MRI) findings in patients with Chiari type 1 malformations who undergo cerebellar tonsillar reduction via electrocautery.

Methods: The extent of cytotoxic edema and microhemorrhages demonstrated on MRI scans obtained within 9 days following surgery was assessed and correlated with neurological symptoms.

Advances in the Radiological Evaluation of and Theranostics for Glioblastoma.

Imaging is essential for evaluating patients with glioblastoma. Traditionally a multimodality undertaking, CT, including CT cerebral blood profusion, PET/CT with traditional fluorine-18 fluorodeoxyglucose (F-FDG), and MRI have been the mainstays for diagnosis and post-therapeutic assessment. However, recent advances in these modalities, in league with the emerging fields of radiomics and theranostics, may prove helpful in improving diagnostic accuracy and treating the disease.

Recent Advances in Deep Learning and Medical Imaging for Head and Neck Cancer Treatment: MRI, CT, and PET Scans.

Deep learning techniques have been developed for analyzing head and neck cancer imaging. This review covers deep learning applications in cancer imaging, emphasizing tumor detection, segmentation, classification, and response prediction. In particular, advanced deep learning techniques, such as convolutional autoencoders, generative adversarial networks (GANs), and transformer models, as well as the limitations of traditional imaging and the complementary roles of deep learning and traditional techniques in cancer management are discussed.

A preliminary diagnostic accuracy study of quantitative MRI biomarkers for differentiating parotid tumor types.

Background: Differentiating among the different types of parotid tumors on imaging is useful for guiding clinical disposition, which ultimately may lead to surgical management. The goal of this study was to determine whether quantitative T2 signal characteristics and morphologic features on magnetic resonance imaging (MRI) can serve as predictive biomarkers for distinguishing between tumor types.

Methods: A retrospective review of T2-weighted MRIs in patients with pathology-proven parotid tumors was performed.

MRI radiomics and potential applications to glioblastoma.

MRI plays an important role in the evaluation of glioblastoma, both at initial diagnosis and follow up after treatment. Quantitative analysis radiomics can augment the interpretation of MRI in terms of providing insights regarding the differential diagnosis, genotype, treatment response, and prognosis. The various MRI radiomic features of glioblastoma are reviewed in this article.

Evaluation of an Automated Reminder System for Reducing Missed MRI Appointments.

The high frequency of missed appointments continues to be a burden on healthcare providers, leading to decreased productivity, quality of service, and quality of outcome. The purpose of this study is to evaluate the effectiveness of Televox's automated appointment reminder service in reducing the missed appointment rate for MRI (magnetic resonance imaging). The appointment reminders were sent 72 h in advance.

Imaging Features of Intratumoral Injection of NBTXR3 for Head and Neck Squamous Cell Carcinoma Lymph Node Metastases.

NBTXR3 nanoparticle injection is a relatively novel radioenhancer for treatment of various cancers. CT scans following NBTXR3 injection of metastatic lymph nodes from head and neck squamous cell carcinoma were reviewed in a small series of patients. The radioenhancing appears as hyperattenuating, with a mean attenuation of the injected material of 1516 HU.

Semantic Segmentation of Extraocular Muscles on Computed Tomography Images Using Convolutional Neural Networks.

Computed tomography (CT) imaging of the orbit with measurement of extraocular muscle size can be useful for diagnosing and monitoring conditions that affect extraocular muscles. However, the manual measurement of extraocular muscle size can be time-consuming and tedious. The purpose of this study is to evaluate the effectiveness of deep learning algorithms in segmenting extraocular muscles and measuring muscle sizes from CT images.

Normal Anatomic Structures, Variants, and Mimics of the Temporal Bone.

Various anatomic structures and variants in the temporal bone are potential radiological mimics and surgical hazards. The imaging features of normal variants and lesions with similar imaging appearance are presented in this article. Throughout the article, salient features that can help elucidate the distinguishing features between mimics and imaging pitfalls are presented.

Implants and Foreign Bodies on Head and Neck Imaging.

A wide variety of foreign bodies can be encountered on head and neck imaging. These foreign bodies might include comestible foreign bodies, retained foreign bodies from trauma, and surgically implanted devices. The imaging features of these items are reviewed in this article.

Postsurgical and Postradiation Findings in the Head and Neck Imaging.

Surgical procedures and radiation therapy can have recognizable features on diagnostic imaging that should be recognized by the radiologist. Although it is a good practice to reference the surgical and clinical notes regarding any procedures that may have been performed in the head and neck, this information is not always available. Selected examples of posttreatment findings and potential mimics are described and depicted in the following sections.

Pearls and Pitfalls of FDG-PET Head and Neck Imaging.

18FDG-PET plays an important role in cancer imaging. However, there are certain challenges with interpreting head and neck 18FDG-PET. In this article, examples of technical issues that can undermine the interpretation of the scans, normal physiologic activity that can mimic lesions or obscure lesions, and causes of false positives and false negatives on posttreatment cancer imaging are discussed.

MR Imaging Artifacts in the Head and Neck Region: Pitfalls and Solutions.

MR Imaging artifacts are features appearing in MR images that are not present in the original anatomy. MR imaging artifacts can be patient-related, hardware-related, or signal-processing-related and affect diagnostic quality or mimic pathology. It is necessary to take MR imaging artifacts into consideration when interpreting images.

Computed Tomography Imaging Artifacts in the Head and Neck Region: Pitfalls and Solutions.

Computed tomography (CT) artifacts are aberrations that usually degrade the image quality of CT images, but occasionally provide insights regarding actual imaging findings. The presence of artifacts can be attributed to various sources, including patient, scanner, and postprocessing factors. Artifacts can lead to diagnostic errors by obscuring findings or by being misinterpreted as actual lesions.

Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma.

Importance: Clinical practice regarding posttreatment radiologic surveillance for patients with oropharyngeal carcinoma (OPC) is neither adapted to individual patient risk nor fully evidence based.

Objectives: To construct a microsimulation model for posttreatment OPC progression and use it to optimize surveillance strategies while accounting for both tumor stage and human papillomavirus (HPV) status.

Design, Setting, And Participants: In this decision analytical modeling study, a Markov model of 3-year posttreatment patient trajectories was created.