Publications by authors named "Gina Patrus"
Introduction: Reactivation of herpes simplex virus (HSV) and varicella zoster virus (VZV) is a potential complication following allogeneic stem cell transplantation (alloSCT). Since different doses and durations of acyclovir prophylaxis may be utilized across transplant centers, this study aimed to evaluate the effectiveness of a lower dose of acyclovir in preventing HSV and VZV reactivation in alloSCT recipients within our institution.
Methods: A retrospective chart review was conducted for patients who underwent alloSCT between April 2016 and May 2023.
Article Synopsis
- - The study investigates the impact of melphalan dosing and chronic kidney disease (CKD) on outcomes in multiple myeloma patients undergoing autologous stem cell transplantation (ASCT), addressing the lack of standard renal dose adjustments.
- - Researchers assessed 124 patients (108 without CKD and 16 with CKD), evaluating metrics such as progression-free survival (PFS), overall survival (OS), and complications, using statistical methods for analysis.
- - Results indicated that while the CKD group had a median PFS of 60 months compared to 46 months for no-CKD patients, there was a notable increase in severe mucositis in the CKD group, highlighting the need for tailored treatment approaches based
Approximately 25,000 allogeneic transplants are performed annually worldwide; a figure that has steadily increased over the past three decades. The study of transplant recipient survivorship has become a cogent topic and post-transplant donor cell pathology warrants further study. Donor cell leukemia (DCL) is a rare but serious complication of allogeneic stem cell transplantation (SCT) where the recipient develops a form leukemia originating from the donor cells used for transplantation.
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