Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation.

We have described a novel cytokine encoded by a gene called Meteorin-like (). Metrnl is a small (∼28 kDa) secreted protein expressed by activated macrophages and barrier tissues (mucosa and skin). Metrnl production by bone marrow macrophages is induced by several cytokines including TNF-α, IL-17α, IL-12, and IL-4 and inhibited by IFN-γ and TGF-β.