Publications by authors named "Gina Mateja"
Contemporary, prospective data regarding the impact of granulocyte-colony stimulating factor (G-CSF) on outcomes after autologous hematopoietic stem cell transplantation (Auto-HSCT) in an era when stem cell grafts are more qualitatively robust are limited. Recent retrospective analyses have not supported a beneficial effect of post-transplantation G-CSF use on major outcomes after Auto-HSCT leading to strategies to delay or eliminate the use of G-CSF altogether in this context. To test the hypothesis that the infusion of consistently higher doses of stem cells (defined as ≥4 × 10/kg) in Auto-HSCT will obviate the need for post-transplantation G-CSF.
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- - Previous studies have indicated that race and socioeconomic status (SES) may negatively influence outcomes after hematopoietic stem cell transplantation (HSCT), particularly affecting minority and disadvantaged groups, but findings have varied due to numerous confounding factors.
- - This research focused on haploidentical (HI) HSCT and aimed to analyze how race and SES impact outcomes, like relapse and overall survival, controlling for medical factors and using a consistent treatment protocol among a diverse cohort of 239 patients.
- - Results revealed that minority patients were more likely to experience complications like cytomegalovirus (CMV) reactivation, which correlated with higher rates of relapse and mortality, highlighting the need to address these disparities in transplant outcomes.