Publications by authors named "Gina Lum"
Maternal inflammatory and microbial drivers of low birthweight in low- and middle-income countries.
Paediatr Int Child Health
August 2024
Article Synopsis
- Low birthweight (LBW) affects 1 in 7 infants in low- and middle-income countries, significantly increasing morbidity and mortality risks, as well as long-term health issues.
- The study reviewed literature on inflammatory, microbial, and infective factors linked to LBW, finding that local and systemic infections in mothers, like vaginitis and HIV, significantly contribute to the condition.
- Although antimicrobial treatments during pregnancy have shown limited overall benefits for birthweight, they may help in high-infection settings; thus, understanding the underlying mechanisms of LBW is crucial for developing effective treatments.
The suppression of the internal standard by increasing concentrations of the co-eluting analyte in calibration series and plasma samples analysed by LC-ESI-MS was studied using the isotope dilution technique. A series of three analyte/deuterated analyte pairs including fexofenadine/d6-fexofenadine, dapsone/d4-dapsone and peudoephedrine/d3-ephedrine were investigated. Suppression of the internal standard signal was noticed in extracted plasma samples containing fexofenadine and d6-fexofenadine as internal standard, as well as in solvent based calibration solutions of the three pair of compounds noted above during LC-ESI-MS analysis at flow rates greater than 100 microL min(-1).
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