Chemical unclonable functions based on operable random DNA pools.

Physical unclonable functions (PUFs) based on unique tokens generated by random manufacturing processes have been proposed as an alternative to mathematical one-way algorithms. However, these tokens are not distributable, which is a disadvantage for decentralized applications. Finding unclonable, yet distributable functions would help bridge this gap and expand the applications of object-bound cryptography.

A digital twin for DNA data storage based on comprehensive quantification of errors and biases.

Archiving data in synthetic DNA offers unprecedented storage density and longevity. Handling and storage introduce errors and biases into DNA-based storage systems, necessitating the use of Error Correction Coding (ECC) which comes at the cost of added redundancy. However, insufficient data on these errors and biases, as well as a lack of modeling tools, limit data-driven ECC development and experimental design.

Current Status Regarding Immunosuppressive Treatment in Patients after Renal Transplantation.

Renal transplantation is now the best treatment for end-stage renal failure. To avoid rejection and prolong graft function, organ recipients need immunosuppressive therapy. The immunosuppressive drugs used depends on many factors, including time since transplantation (induction or maintenance), aetiology of the disease, and/or condition of the graft.

Ecological effects of offshore wind farms on Atlantic cod (Gadus morhua) in the southern North Sea.

Evaluating the ecological effects of the rapid expansion of offshore renewables at local, regional and ecosystem-wide scales is essential to understand the overall socio-ecological trade-offs also for other sectors such as fisheries. Hence, little is known about the ecological impact on demersal fish. To shed light on this topic, we studied the effects of an offshore wind farm in the southern North Sea on different life stages of Atlantic cod (Gadus morhua) using a combination of sampling methods at varying spatial and temporal scales.

Information decay and enzymatic information recovery for DNA data storage.

Synthetic DNA has been proposed as a storage medium for digital information due to its high theoretical storage density and anticipated long storage horizons. However, under all ambient storage conditions, DNA undergoes a slow chemical decay process resulting in nicked (broken) DNA strands, and the information stored in these strands is no longer readable. In this work we design an enzymatic repair procedure, which is applicable to the DNA pool prior to readout and can partially reverse the damage.

Emerging Approaches to DNA Data Storage: Challenges and Prospects.

With the total amount of worldwide data skyrocketing, the global data storage demand is predicted to grow to 1.75 × 10 GB by 2025. Traditional storage methods have difficulties keeping pace given that current storage media have a maximum density of 10 GB/mm.

IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes.

Neutrophil extracellular trap (NET) formation is a powerful instrument to fight pathogens, but may induce collateral damage in the affected tissues. Besides pathogen-derived factors, immune complexes are potent inducers of NET formation. Neutrophils express IgA and IgG specific Fc receptors (FcRs) and therefore respond to complexed IgA and IgG.

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies.

The optimization of upstream and downstream processes for production of recombinant adeno-associated virus (rAAV) with consistent quality depends on the ability to rapidly characterize critical quality attributes (CQAs). In the context of rAAV production, the virus titer, capsid content, and aggregation are identified as potential CQAs, affecting the potency, purity, and safety of rAAV-mediated gene therapy products. Analytical methods to measure these attributes commonly suffer from long turnaround times or low throughput for process development, although rapid, high-throughput methods are beginning to be developed and commercialized.

Sustainable co-location solutions for offshore wind farms and fisheries need to account for socio-ecological trade-offs.

The spatial expansion of offshore wind farms (OWFs) is key for the transition to a carbon free energy sector. In the North Sea, the sprawl of OWFs is regulated by marine spatial planning (MSP) and results in an increasing loss of space for other sectors such as fisheries. Understanding fisheries benefits of OWFs and mitigating the loss of fishing grounds is key for co-location solutions in MSP.

Risk factors and maternal outcomes following preterm premature rupture of membrane in the second trimester of gestation.

Purpose: To characterize the population of women who underwent mid-trimester preterm premature rupture of membrane (PPROM) in a country where mid-trimester abortions are legal and available.

Methods: A retrospective cross-sectional cohort study was conducted at a tertiary referral hospital, during 2013-2016. Mid-trimester defined as gestational age 13 + 0 to 23 + 6 weeks.

A spatial risk approach towards integrated marine spatial planning: A case study on European hake nursery areas in the North Alboran Sea.

Europe's Blue Growth strategy promotes the intensification of human activities at sea and increases the environmental risk such as the decline of the provision of key ecosystem services and potential conflicts among human activities. The fishing sector, in the Alboran Sea, is economically and culturally one of the most important and relies on overexploited target species such as European hake (Merlucius merlucius). Here we identified and quantified the impact of human pressures on the capacity of marine habitats to support the provision of food as an important ecosystem service.

A GIS-based tool for an integrated assessment of spatial planning trade-offs with aquaculture.

The increasing demand for protein from aquaculture will trigger a global expansion of the sector in coastal and offshore waters. While contributing to food security, potential conflicts with other traditional activities such as fisheries or tourism are inevitable, thus calling for decision-support tools to assess aquaculture planning scenarios in a multi-use context. Here we introduce the AquaSpace tool, one of the first Geographic Information System (GIS)-based planning tools empowering an integrated assessment and mapping of 30 indicators reflecting economic, environmental, inter-sectorial and socio-cultural risks and opportunities for proposed aquaculture systems in a marine environment.

A spatially explicit risk approach to support marine spatial planning in the German EEZ.

An ecosystem approach to marine spatial planning (MSP) promotes sustainable development by organizing human activities in a geo-spatial and temporal context. (1) This study develops and tests a spatially explicit risk assessment to support MSP. Using the German exclusive economic zone (EEZ) of the North Sea as a case study area, current and future spatial management scenarios are assessed.