Mononuclear cell phagocytosis in giant cell lesions of the jaws.

Background And Objective: The central giant cell lesion (CGCL) is a benign intraosseous lesion that may resemble other giant cell-rich lesions, such as the peripheral giant cell lesion (PGCL). This lesion may be classified as aggressive or non-aggressive according to clinical and radiographic criteria, however, there is no biological marker that may help to define the CGCL based on the biological behavior. In this context, stromal cell phagocytosis has been described as an event related to aggressive lesions, however, only a few studies have investigated this phenomenon in CGCL.