Intrinsic sympathomimetic activity (ISA) of pindolol in patients with sinus node dysfunction.

The effects of pindolol treatment on mean heart rate (MHR) and the number of paced heart beats were investigated in a group of 12 patients, with frequency programmable pacemakers implanted to control symptomatic bradyarrhythmias resulting from sinus node dysfunction. In a randomized double blind cross over experiment the patients were treated with pindolol (5 mg t.i.

Effects of intravenous captopril on inducible sustained ventricular tachycardia one week after experimental infarction in the anaesthetized pig.

The effect of captopril on inducible sustained ventricular tachycardia (VT) one week after myocardial infarction was studied in 6 Yorkshire swine. In 24 pigs, controlled myocardial infarction (MI) was produced by reversible occlusion of the left anterior descending artery during 60 minutes using an inflatable balloon catheter. Four animals died during this procedure and another 4 during the first week.

Sustained protection by iloprost of the porcine heart in the acute and chronic phases of myocardial infarction.

The effects of iloprost (ZK 36 374) on myocardial ischemia and infarction were studied in three groups of four anesthetized and heparinized pigs. Coronary microembolization was evoked by the injection of microspheres (50 microM) into the left coronary artery. A dose of 12 million beads/kg was followed by ventricular fibrillation and death after 11 +/- 5 min (group A).

Improved recovery of cardiac function after 24 h of hypothermic arrest in the isolated rat heart: comparison of a prostacyclin analogue (ZK 36 374) and a calcium entry blocker (diltiazem).

The effects of a stable prostacyclin analogue (ZK 36 374; 4 nM) and a calcium entry blocker (diltiazem; 50 nM) on the recovery of cardiac function after 24 h of hypothermic (10 degrees C) cardiac arrest were studied in the isolated rat heart. Recovery of the pressure-rate index of treated hearts was significantly better [59 +/- 10% for diltiazem (p less than 0.05) and 51 +/- 7% for ZK 36 374 (p less than 0.

Captopril reduces purine loss and reperfusion arrhythmias in the rat heart after coronary artery occlusion.

Captopril was perfused through isolated rat hearts; its effects after local ischemia and reperfusion were assessed. Upon reperfusion all untreated (10 out of 10) but only 4 (out of 10) captopril-treated (80 micrograms/ml) hearts fibrillated (P less than 0.02).

Biphasic positive inotropic actions of ouabain on rat, guinea-pig and cat heart: a mathematical description.

The inotropic action of ouabain on isolated perfused hearts of rat, guinea-pig, and cat was studied over a wide concentration range (10(-12)-5 X 10(-3) M). In all three species used, the positive inotropic effect (PIE) of ouabain appeared to be biphasic in character. However, there was a remarkable difference in the course of the logdose-response curves of ouabain on guinea-pig and cat heart as compared with than on rat heart.

Improved functional recovery of the isolated rat heart after 24 hours of hypothermic arrest with a stable prostacyclin analogue (ZK 36 374).

Prostacyclin (PGI2) can protect the heart against ischemia, i.e. it can reduce myocardial damage [9, 10].

Intradaily variation of the human lower leg length and short term growth--a longitudinal study in fourteen children.

In order to detect the intradaily variation of the lower leg length in fourteen children the right lower leg length was determined using a non-invasive lower leg length measuring device at three set times of each day during a study period of three weeks. The mean standard error of the determinations amounted to 0.04 mm.

A concentration-dependent biphasic positive inotropic action of ouabain on isolated heart of rat and guinea-pig.

Log dose-response curves of ouabain on rat and guinea-pig heart revealed the existence of a concentration-dependent, biphasic inotropic effect of ouabain. With rat as with guinea pig heart the "first" effect observed at the lowest concentrations of ouabain, was relatively small (rat: 115% of control, at 10(-6) M ouabain; guinea-pig: 110% of control, at 6.25.