The effect of enriched versus depleted housing on eucalyptus smoke-induced cardiovascular dysfunction in mice.

Living conditions play a major role in health and well-being, particularly for the cardiovascular and pulmonary systems. Depleted housing contributes to impairment and development of disease, but how it impacts body resiliency during exposure to environmental stressors is unknown. This study examined the effect of depleted (DH) versus enriched housing (EH) on cardiopulmonary function and subsequent responses to wildfire smoke.

Evaluation of behavioural, chemical, toxicological and clinical studies of a tobacco heated product glo™ and the potential for bridging from a foundational dataset to new product iterations.

Background: Tobacco Heating Products (THPs) are tobacco products that heat rather than burn tobacco with temperatures less than 350 °C. Because of this operating principle, they produce substantially fewer and lower levels of tobacco smoke toxicants than combustible cigarette smoke produced when tobacco is burnt, which occurs at much higher temperatures of around 900 °C. This paper analyses data on a THP, glo™, and assesses whether its use would result in reduced health risks compared to the health risks of smoking cigarettes.

NeoSTRESS: Study of Transfer and Retrieval Environmental StressorS upon neonates via a smartphone application - Sound.

Aim: This study aimed to measure sound exposure during neonatal retrieval, determine whether this varied with mode of transport, and compare noise exposure to recommended levels in neonatal intensive care units. We also aimed to assess the acceptability of using a smartphone application to measure sound.

Setting: Neonatal retrieval service in Brisbane, Australia.

NeoSTRESS: Study of Transfer and Retrieval Environmental StressorS Upon Neonates via a Smartphone Application-Light.

Objective: This study aimed to measure the light levels neonates would be exposed to during retrieval, determine whether this varied with transport mode, and compare them with recommended light exposure in neonatal intensive care units. We also aimed to determine the ease of use and acceptability of using the smartphone application.

Setting: A neonatal retrieval service in Brisbane, Australia.

Defining Multiple Characteristic Raman Bands of α-Amino Acids as Biomarkers for Planetary Missions Using a Statistical Method.

Biomarker molecules, such as amino acids, are key to discovering whether life exists elsewhere in the Solar System. Raman spectroscopy, a technique capable of detecting biomarkers, will be on board future planetary missions including the ExoMars rover. Generally, the position of the strongest band in the spectra of amino acids is reported as the identifying band.

Multiple Cosmic Sources for Meteorite Macromolecules?

The major organic component in carbonaceous meteorites is an organic macromolecular material. The Murchison macromolecular material comprises aromatic units connected by aliphatic and heteroatom-containing linkages or occluded within the wider structure. The macromolecular material source environment remains elusive.

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.

Background: Human respiratory epithelia function in airway mucociliary clearance and barrier function and have recently been implicated in sensory functions.

Objective: We investigated a link between chronic obstructive pulmonary disease (COPD) pathogenesis and molecular mechanisms underlying Ca2+ influx into human airway epithelia elicited by diesel exhaust particles (DEP).

Methods And Results: Using primary cultures of human respiratory epithelial (HRE) cells, we determined that these cells possess proteolytic signaling machinery, whereby proteinase-activated receptor-2 (PAR-2) activates Ca2+-permeable TRPV4, which leads to activation of human respiratory disease-enhancing matrix metalloproteinase-1 (MMP-1), a signaling cascade initiated by diesel exhaust particles (DEP), a globally relevant air pollutant.

The microbe-mineral environment and gypsum neogenesis in a weathered polar evaporite.

Evaporitic deposits are a globally widespread habitat for micro-organisms. The microbe-mineral environment in weathered and remobilized gypsum from exposed mid-Ordovician marine evaporite beds in the polar desert of Devon Island, Nunavut, Canadian High Arctic was examined. The gypsum is characterized by internal green zones of cyanobacterial colonization (dominated by Gloeocapsa/Aphanothece and Chroococcidiopsis spp.

Management of cardiac health in trastuzumab-treated patients with breast cancer: updated United Kingdom National Cancer Research Institute recommendations for monitoring.

More women are living with and surviving breast cancer, because of improvements in breast cancer care. Trastuzumab (Herceptin) has significantly improved outcomes for women with HER2-positive tumours. Concerns about the cardiac effects of trastuzumab (which fundamentally differ from the permanent myocyte loss associated with anthracyclines) led to the development of cardiac guidelines for adjuvant trials, which are used to monitor patient safety in clinical practice.

Traffic and meteorological impacts on near-road air quality: summary of methods and trends from the Raleigh Near-Road Study.

A growing number of epidemiological studies conducted worldwide suggest an increase in the occurrence of adverse health effects in populations living, working, or going to school near major roadways. A study was designed to assess traffic emissions impacts on air quality and particle toxicity near a heavily traveled highway. In an attempt to describe the complex mixture of pollutants and atmospheric transport mechanisms affecting pollutant dispersion in this near-highway environment, several real-time and time-integrated sampling devices measured air quality concentrations at multiple distances and heights from the road.

Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells.

In vivo exposure to diesel exhaust particles (DEP) elicits acute inflammatory responses in the lung characterized by inflammatory cell influx and elevated expression of mediators such as cytokines and chemokines. Signal transducers and activators of transcription (STAT) proteins are a family of cytoplasmic transcription factors that are key transducers of signaling in response to cytokine and growth factor stimulation. One member of the STAT family, Stat3, has been implicated as a regulator of inflammation but has not been studied in regard to DEP exposure.

Compound-specific isotope analysis of the organic constituents in carbonaceous chondrites.

The carbonaceous chondrite meteorites contain evidence of the formation of the solar system, part of which is present within organic matter. In recent years, compound-specific isotope analysis (CSIA) has been useful in deciphering this complex record. The current published data set provides an insight into the source environments and reaction mechanisms that have contributed to the final state of the organic constituents in carbonaceous chondrites.

The use of stable carbon isotope analysis to detect the abuse of testosterone in cattle.

The use of stable carbon isotope analysis to detect the administration of anabolic steroids to cattle was investigated. Samples were extracted by solid-phase extraction on C18 cartridges. Stable isotope ratios (13C:12C) were measured by gas chromatography-isotope ratio mass spectrometry (GC-IRMS) of the underivatised extracts.

Altered alveolar macrophage function in calorie-restricted rats.

Alveolar macrophage functions associated with clearance of bacteria from the lung were assessed in male Fischer 344 rats maintained on a 25% calorie-restricted diet. Calorie-restricted and ad libitum-fed (control) rats were exposed to concentrations of ozone known to compromise phagocytic function of alveolar macrophages. Ozone suppressed alveolar macrophage phagocytosis of latex beads in vitro in ad libitum-fed rats, but not in calorie-restricted rats.

Isolation and characterization of an attenuated strain of Pseudomonas aeruginosa AC869, a 3,5-dichlorobenzoate degrader.

Pseudomonas aeruginosa AC869, a 3,5-dichlorobenzoate degrader, is a mouse pathogen and has a reported 50% lethal dose (LD50) of 1.05 x 10(7) CFU when given intranasally to C3H/HeJ mice (S.E.

Comparison of antialgal activity of brown-rotted and white-rotted wood andIn situ analysis of lignin.

Brown-rotted wood has been used as a source of lignin to investigate further the antialgal effects of lignocellulosic materials such as decomposing barley straw. The antialgal activity of brown-rotted and white-rotted wood has been determined in a laboratory bioassay. Using pyrolysis gas chromatography-mass spectrometry, the lignin of the rotted wood samples has been compared and the significance of the structure of the lignin in antialgal activity is discussed.

Safety and efficacy of a ventilator database interface.

This report describes a ventilator dysfunction that arose during the mechanical ventilation of a lung transplant recipient. The problem was discovered because the data on the computer-based information management system (CIMS) was different from that on the ventilator's dials. This incident is important because of the continued extensive use of analog mechanical ventilators, the increasing popularity of CIMS, and the patient safety implications of the incident.

The effects of circuit and humidifier type on contamination potential during mechanical ventilation: a laboratory study.

Background: This study was undertaken because of concerns that ventilator humidifiers could be exacerbating the problem of nosocomial pneumonia in patients receiving mechanical ventilation.

Methods: Four different brands of humidifiers were used in conjunction with a siemens Servo 900B mechanical ventilator (Siemens Life Support Services, Solna, Sweden). In the first part, the ventilator was operated with humidifiers filled with contaminated water at room temperature.

Ondansetron prevents postoperative nausea and vomiting in women outpatients.

Three doses of intravenous (i.v.) ondansetron, 1 mg, 4 mg, and 8 mg, were compared to placebo for their antiemetic effect and safety.

The effect of heated wire circuits on humidification of inspired gases.

We performed this study to determine the effect of heated wire circuits on humidity delivered by several humidifiers commonly used during anesthesia. Humidifier bases from three manufacturers with several humidifying chambers for each base were tested using both heated and unheated circuits. Delivered humidity and circuit temperature were measured at the distal end of the circuit.

Clinical performance of a blood gas monitor: a prospective, multicenter trial.

Objective: To prospectively assess the clinical performance of a fluorescent optode-based blood gas monitoring system that is designed to perform arterial pH, PCO2, and PO2 measurements as frequently as clinically required without violating the integrity of the arterial catheter tubing system or permanently removing blood from the patient.

Design: A prospective, multicenter study to compare modern blood gas analyzer measurements with the coinciding measurements of the blood gas monitoring system.

Setting: Four intensive care units (ICUs) in academic centers with varying patient populations, blood gas measurement routines, and blood gas laboratory facilities.