[The dental status of patients with gastroesophageal reflux disease depending on the intake of proton pump inhibitors].

Unlabelled: The number of men and women with gastroesophageal reflux disease (GERB) is increasing each year; besides, the disease seeks rejuvenation. Because the oral cavity is the initial digestive system, gastrointestinal tract diseases (GT) and associated changes in the oral cavity are closely related.

The Aim Of The Study: Was to assess the dental status of patients with gastroesophageal reflux disease depending on the use of proton pump inhibitors based on the comprehensive clinical and laboratory study.

[Сlinicmolecular indicators of inflammatory destructive damage of the oral cavity in periodontitis in persons with various group accessories of blood.].

In order to find a connection between the alteration of oral tissues and genetic predisposition to inflammatory and destructive processes in oral media, the cytokine profile of the oral fluid of clinically healthy individuals was determined for various blood group affiliations according to the AB0 system. The group-specific features of individuals with B(III) blood group were revealed: an increase of 32,5% in the content of interleukin-6 and 63,1% in the content of interleukin-8 compared with similar data for people with 0(I), A(II), AB(IV) blood groups, which can predispose to the greatest activity of the inflammatory process in the oral cavity in individuals with antigen B. Confirmation of this fact is an increase of IgA antibodies to gliadin in the blood among patients with chronic generalized periodontitis with B(III) blood group, up to 5,00 U/ml (p<0,01), which indicates the processes of acute inflammation, and along with an increase in blood IgG antibodies to transglutaminase in comparison with a group of clinically healthy individuals, it serves as an indicator of damage to the body's connective tissue at the molecular level.

[Coagulation test features depending on the AB0-blood groups system antigenic composition.].

The maintenance of normal blood flow through the vessels is the result of the coordinated work of the coagulation and anticoagulation systems of our body. The balance of this system depends on many factors, including endothelial, humoral, platelet ones, however, we still lack knowledge about the effect of antigenic determinants on the state of the hemostatic system. This study is devoted to assessing the effect of the presence and absence of antigens on the AB0 system, presented on erythrocyte and platelet membranes, on hemostatic parameters.

[Molecular markers of the oral mucosa damage in patients with leukemia.].

The criteria for early manifestations of mucosal lesions in patients with acute and chronic leukemia are distinguished: in the absence of complaints and changes in the index assessment of the oral cavity, a block of initial dental signs in the form of edema of the tongue and the smoothness of its papillae, pallor of the oral mucosa in patients with leukemia. In theoral fluid of patients with the initial signs of dental pathology in acute leukemia, a specific spectrum of disorders was established in the form of the lowest antibody level of immunoglobulin A class to transglutaminase in combination with a high amount of Ig G antibodies to transglutaminase - 8.73 ± 0.